Measurement of left ventricular volume in normal and volume-overloaded canine hearts.

Published

Journal Article

Serial studies of adaptation to aortic regurgitation (AR) were undertaken to determine whether sonomicrometry and echocardiography could be combined to measure changes in left ventricular (LV) cavitary volume (Vlv) and wall mass using the geometric formula [Vlv = K pi b2 alpha--wall volume], where K is a constant depending on the geometric model and a and be are epicardial major- and minor-axis diameters, respectively. Postmortem studies were performed in six normal dogs and in nine with AR; ultrasonic ventricular dimensions were measured as Vlv was varied with an intracavitary balloon. Three models were tested: 1) ellipsoid (model I; K = 1/6), 2) cylinder-ellipsoid (model II; K = 5/24), and 3) cylinder (model III; K = 1/4). The slope of the relationship between calculated Vlv and balloon volume varied between models (I, 0.71 +/- 0.11; II, 0.89 +/- 0.14; III, 1.07 +/- 0.17), and empiric determination of K to produce a slope of 1.0 resulted in a value of 0.26 +/- 0.04, not significantly different from the cylindrical model. Serial measurements of LV dimensions in 10 chronically instrumented conscious dogs revealed no significant change in end-diastolic or end-ejection LV shape after up to 16 wk of AR. Sonomicrometry and echocardiography can be integrated using a cylindrical geometric model to accurately estimate changes in end-diastolic or end-ejection Vlv during chronic volume overload.

Full Text

Duke Authors

Cited Authors

  • Gaynor, JW; Feneley, MP; Gall, SA; Maier, GW; Kisslo, JA; Davis, JW; Rankin, JS; Glower, DD

Published Date

  • January 1, 1994

Published In

Volume / Issue

  • 266 / 1 Pt 2

Start / End Page

  • H329 - H340

PubMed ID

  • 8304515

Pubmed Central ID

  • 8304515

Electronic International Standard Serial Number (EISSN)

  • 2163-5773

International Standard Serial Number (ISSN)

  • 0002-9513

Digital Object Identifier (DOI)

  • 10.1152/ajpheart.1994.266.1.h329

Language

  • eng