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Measurement of left ventricular volume in normal and volume-overloaded canine hearts.

Publication ,  Journal Article
Gaynor, JW; Feneley, MP; Gall, SA; Maier, GW; Kisslo, JA; Davis, JW; Rankin, JS; Glower, DD
Published in: Am J Physiol
January 1994

Serial studies of adaptation to aortic regurgitation (AR) were undertaken to determine whether sonomicrometry and echocardiography could be combined to measure changes in left ventricular (LV) cavitary volume (Vlv) and wall mass using the geometric formula [Vlv = K pi b2 alpha--wall volume], where K is a constant depending on the geometric model and a and be are epicardial major- and minor-axis diameters, respectively. Postmortem studies were performed in six normal dogs and in nine with AR; ultrasonic ventricular dimensions were measured as Vlv was varied with an intracavitary balloon. Three models were tested: 1) ellipsoid (model I; K = 1/6), 2) cylinder-ellipsoid (model II; K = 5/24), and 3) cylinder (model III; K = 1/4). The slope of the relationship between calculated Vlv and balloon volume varied between models (I, 0.71 +/- 0.11; II, 0.89 +/- 0.14; III, 1.07 +/- 0.17), and empiric determination of K to produce a slope of 1.0 resulted in a value of 0.26 +/- 0.04, not significantly different from the cylindrical model. Serial measurements of LV dimensions in 10 chronically instrumented conscious dogs revealed no significant change in end-diastolic or end-ejection LV shape after up to 16 wk of AR. Sonomicrometry and echocardiography can be integrated using a cylindrical geometric model to accurately estimate changes in end-diastolic or end-ejection Vlv during chronic volume overload.

Duke Scholars

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

January 1994

Volume

266

Issue

1 Pt 2

Start / End Page

H329 / H340

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Regression Analysis
  • Reference Values
  • Models, Cardiovascular
  • In Vitro Techniques
  • Hyperemia
  • Heart
  • Echocardiography
  • Dogs
  • Cardiovascular System & Hematology
 

Citation

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Gaynor, J. W., Feneley, M. P., Gall, S. A., Maier, G. W., Kisslo, J. A., Davis, J. W., … Glower, D. D. (1994). Measurement of left ventricular volume in normal and volume-overloaded canine hearts. Am J Physiol, 266(1 Pt 2), H329–H340. https://doi.org/10.1152/ajpheart.1994.266.1.H329
Gaynor, J. W., M. P. Feneley, S. A. Gall, G. W. Maier, J. A. Kisslo, J. W. Davis, J. S. Rankin, and D. D. Glower. “Measurement of left ventricular volume in normal and volume-overloaded canine hearts.Am J Physiol 266, no. 1 Pt 2 (January 1994): H329–40. https://doi.org/10.1152/ajpheart.1994.266.1.H329.
Gaynor JW, Feneley MP, Gall SA, Maier GW, Kisslo JA, Davis JW, et al. Measurement of left ventricular volume in normal and volume-overloaded canine hearts. Am J Physiol. 1994 Jan;266(1 Pt 2):H329–40.
Gaynor, J. W., et al. “Measurement of left ventricular volume in normal and volume-overloaded canine hearts.Am J Physiol, vol. 266, no. 1 Pt 2, Jan. 1994, pp. H329–40. Pubmed, doi:10.1152/ajpheart.1994.266.1.H329.
Gaynor JW, Feneley MP, Gall SA, Maier GW, Kisslo JA, Davis JW, Rankin JS, Glower DD. Measurement of left ventricular volume in normal and volume-overloaded canine hearts. Am J Physiol. 1994 Jan;266(1 Pt 2):H329–H340.

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

January 1994

Volume

266

Issue

1 Pt 2

Start / End Page

H329 / H340

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Regression Analysis
  • Reference Values
  • Models, Cardiovascular
  • In Vitro Techniques
  • Hyperemia
  • Heart
  • Echocardiography
  • Dogs
  • Cardiovascular System & Hematology