Effects of arterial hypertension on myocardial recovery after ischemic injury.


Journal Article

Although improved surgery, angioplasty, and thrombolysis have made early revascularization of ischemic myocardium commonplace, the effects of arterial hypertension on myocardial recovery remain unclear. Therefore eight conscious dogs were instrumented to measure left ventricular transmural pressure and myocardial segment length in the left anterior descending (LAD) coronary distribution. Reversible ischemic injury was produced by two 15-min LAD occlusions separated by 4 days of reperfusion, with each dog randomly receiving either phenylephrine or placebo infusion for 30 min beginning 1 h after reperfusion. With ischemia, systolic myocardial performance fell to 14.3 +/- 3.7% of control and required greater than 48 h to recover. Compared with placebo, phenylephrine significantly depressed recovery of systolic function assessed by systolic shortening (57 +/- 12 vs. 85 +/- 13% control) or the area under the stroke work vs. end-diastolic length relationship (62 +/- 14 vs. 93 +/- 7% control) (both P less than 0.05). These data imply that ischemically injured myocardium is highly sensitive to arterial hypertension and that ventricular loading is a major determinant of the rate of myocardial recovery.

Full Text

Duke Authors

Cited Authors

  • Elbeery, JR; Williams, RF; Rankin, JS; Glower, DD; Sabiston, DC; Van Trigt, P

Published Date

  • August 1992

Published In

Volume / Issue

  • 263 / 2 Pt 2

Start / End Page

  • H559 - H564

PubMed ID

  • 1510153

Pubmed Central ID

  • 1510153

International Standard Serial Number (ISSN)

  • 0002-9513

Digital Object Identifier (DOI)

  • 10.1152/ajpheart.1992.263.2.H559


  • eng

Conference Location

  • United States