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Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid.

Publication ,  Journal Article
Li, L; Yoo, H; Becker, FF; Ali-Osman, F; Chan, JY
Published in: Biochem Biophys Res Commun
January 17, 1995

We have identified and sequenced a new gene from human cells that is responsive to DNA damage and retinoic acid treatment, and it is highly expressed in brain and reproductive organs (BRE). This BRE gene encodes an mRNA of 1.7-1.9 kb, with an open reading frame of 1,149 bp, and gives rise to a deduced polypeptide of 383 amino acid residues. Treatment of fibroblast cell with UV and 4-nitroquinoline-1-oxide caused more than 90% and 50% decreases in BRE mRNA, respectively. Similar decreases in BRE expression were observed in RA-treatment of the brain glioma cell U-251 and the promyelocytic cell HL-60. Decrease in BRE mRNA was also observed in a squamous carcinoma cell, 1483, that showed X-ray resistance and has a more aggressive tumorigenic phenotype, but BRE expression was unchanged in cells after growth inhibition. These data indicate that BRE is a house-keeping gene and it may play a role in homeostatis or in certain pathways of differentiation in cells of neural, epithelial and germ line origins.

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Published In

Biochem Biophys Res Commun

DOI

ISSN

0006-291X

Publication Date

January 17, 1995

Volume

206

Issue

2

Start / End Page

764 / 774

Location

United States

Related Subject Headings

  • Ultraviolet Rays
  • Tumor Cells, Cultured
  • Tretinoin
  • Sequence Homology, Amino Acid
  • Rats, Sprague-Dawley
  • Rats
  • Organ Specificity
  • Nerve Tissue Proteins
  • Molecular Sequence Data
  • Male
 

Citation

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Li, L., Yoo, H., Becker, F. F., Ali-Osman, F., & Chan, J. Y. (1995). Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid. Biochem Biophys Res Commun, 206(2), 764–774. https://doi.org/10.1006/bbrc.1995.1108
Li, L., H. Yoo, F. F. Becker, F. Ali-Osman, and J. Y. Chan. “Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid.Biochem Biophys Res Commun 206, no. 2 (January 17, 1995): 764–74. https://doi.org/10.1006/bbrc.1995.1108.
Li L, Yoo H, Becker FF, Ali-Osman F, Chan JY. Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid. Biochem Biophys Res Commun. 1995 Jan 17;206(2):764–74.
Li, L., et al. “Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid.Biochem Biophys Res Commun, vol. 206, no. 2, Jan. 1995, pp. 764–74. Pubmed, doi:10.1006/bbrc.1995.1108.
Li L, Yoo H, Becker FF, Ali-Osman F, Chan JY. Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid. Biochem Biophys Res Commun. 1995 Jan 17;206(2):764–774.
Journal cover image

Published In

Biochem Biophys Res Commun

DOI

ISSN

0006-291X

Publication Date

January 17, 1995

Volume

206

Issue

2

Start / End Page

764 / 774

Location

United States

Related Subject Headings

  • Ultraviolet Rays
  • Tumor Cells, Cultured
  • Tretinoin
  • Sequence Homology, Amino Acid
  • Rats, Sprague-Dawley
  • Rats
  • Organ Specificity
  • Nerve Tissue Proteins
  • Molecular Sequence Data
  • Male