Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23.
Publication
, Journal Article
Li, J; Yang, Y; Peng, Y; Austin, RJ; van Eyndhoven, WG; Nguyen, KCQ; Gabriele, T; McCurrach, ME; Marks, JR; Hoey, T; Lowe, SW; Powers, S
Published in: Nat Genet
June 2002
We found that PPM1D, encoding a serine/threonine protein phosphatase, lies within an epicenter of the region at 17q23 that is amplified in breast cancer. We show that overexpression of this gene confers two oncogenic phenotypes on cells in culture: attenuation of apoptosis induced by serum starvation and transformation of primary cells in cooperation with RAS.
Duke Scholars
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Published In
Nat Genet
DOI
ISSN
1061-4036
Publication Date
June 2002
Volume
31
Issue
2
Start / End Page
133 / 134
Location
United States
Related Subject Headings
- Protein Phosphatase 2C
- Phosphoprotein Phosphatases
- Oncogenes
- Neoplasm Proteins
- Humans
- Gene Amplification
- Female
- Developmental Biology
- Chromosomes, Human, Pair 17
- Cell Transformation, Neoplastic
Citation
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Chicago
ICMJE
MLA
NLM
Li, J., Yang, Y., Peng, Y., Austin, R. J., van Eyndhoven, W. G., Nguyen, K. C. Q., … Powers, S. (2002). Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. Nat Genet, 31(2), 133–134. https://doi.org/10.1038/ng888
Li, Jing, Ying Yang, Yue Peng, Richard J. Austin, Winfried G. van Eyndhoven, Ken C. Q. Nguyen, Tim Gabriele, et al. “Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23.” Nat Genet 31, no. 2 (June 2002): 133–34. https://doi.org/10.1038/ng888.
Li J, Yang Y, Peng Y, Austin RJ, van Eyndhoven WG, Nguyen KCQ, et al. Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. Nat Genet. 2002 Jun;31(2):133–4.
Li, Jing, et al. “Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23.” Nat Genet, vol. 31, no. 2, June 2002, pp. 133–34. Pubmed, doi:10.1038/ng888.
Li J, Yang Y, Peng Y, Austin RJ, van Eyndhoven WG, Nguyen KCQ, Gabriele T, McCurrach ME, Marks JR, Hoey T, Lowe SW, Powers S. Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. Nat Genet. 2002 Jun;31(2):133–134.
Published In
Nat Genet
DOI
ISSN
1061-4036
Publication Date
June 2002
Volume
31
Issue
2
Start / End Page
133 / 134
Location
United States
Related Subject Headings
- Protein Phosphatase 2C
- Phosphoprotein Phosphatases
- Oncogenes
- Neoplasm Proteins
- Humans
- Gene Amplification
- Female
- Developmental Biology
- Chromosomes, Human, Pair 17
- Cell Transformation, Neoplastic