Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23.

Journal Article (Journal Article)

We found that PPM1D, encoding a serine/threonine protein phosphatase, lies within an epicenter of the region at 17q23 that is amplified in breast cancer. We show that overexpression of this gene confers two oncogenic phenotypes on cells in culture: attenuation of apoptosis induced by serum starvation and transformation of primary cells in cooperation with RAS.

Full Text

Duke Authors

Cited Authors

  • Li, J; Yang, Y; Peng, Y; Austin, RJ; van Eyndhoven, WG; Nguyen, KCQ; Gabriele, T; McCurrach, ME; Marks, JR; Hoey, T; Lowe, SW; Powers, S

Published Date

  • June 2002

Published In

Volume / Issue

  • 31 / 2

Start / End Page

  • 133 - 134

PubMed ID

  • 12021784

International Standard Serial Number (ISSN)

  • 1061-4036

Digital Object Identifier (DOI)

  • 10.1038/ng888


  • eng

Conference Location

  • United States