Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene.
Published
Journal Article
Representational difference analysis (RDA) of human breast cancer was used to discover a novel amplicon located at chromosomal region 8q24.3. We examined a series of breast cancer samples harboring amplification of this region and determined that KCNK9 is the sole overexpressed gene within the amplification epicenter. KCNK9 encodes a potassium channel that is amplified from 3-fold to 10-fold in 10% of breast tumors and overexpressed from 5-fold to over 100-fold in 44% of breast tumors. Overexpression of KCNK9 in cell lines promotes tumor formation and confers resistance to both hypoxia and serum deprivation, suggesting that its amplification and overexpression plays a physiologically important role in human breast cancer.
Full Text
Duke Authors
Cited Authors
- Mu, D; Chen, L; Zhang, X; See, L-H; Koch, CM; Yen, C; Tong, JJ; Spiegel, L; Nguyen, KCQ; Servoss, A; Peng, Y; Pei, L; Marks, JR; Lowe, S; Hoey, T; Jan, LY; McCombie, WR; Wigler, MH; Powers, S
Published Date
- March 2003
Published In
Volume / Issue
- 3 / 3
Start / End Page
- 297 - 302
PubMed ID
- 12676587
Pubmed Central ID
- 12676587
International Standard Serial Number (ISSN)
- 1535-6108
Digital Object Identifier (DOI)
- 10.1016/s1535-6108(03)00054-0
Language
- eng
Conference Location
- United States