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Alteration of digoxin pharmacokinetics by a single dose of quinidine.

Publication ,  Journal Article
Chen, TS; Friedman, HS
Published in: JAMA
August 15, 1980

To determine whether a single dose of quinidine sulfate might alter serum digoxin levels, patients receiving maintenance digoxin therapy who required quinidine had their serum digoxin levels measured after oral administration of digoxin, quinidine, or both. In group 1, digoxin and quinidine were administered orally together; in group 2, digoxin was administered orally alone; and in group 3, quinidine was administered orally, 24 hours after the last dose of digoxin. In group 1, serum digoxin level increased by 2.0+/-0.4 ng/mL (from 1.0+/-0.1 ng/mL), but in group 2, serum digoxin level increased by only 1.0+/-0.1 ng/mL (from 1.0+/-0.1 ng/mL). Group 3 showed no change in serum digoxin concentration. Time of maximum digoxin concentration also occurred earlier when digoxin and quinidine were administered together. Thus, a single dose of quinidine will increase the peak digoxin level when administered together with oral digoxin.

Duke Scholars

Published In

JAMA

ISSN

0098-7484

Publication Date

August 15, 1980

Volume

244

Issue

7

Start / End Page

669 / 672

Location

United States

Related Subject Headings

  • Time Factors
  • Quinidine
  • Middle Aged
  • Male
  • Humans
  • General & Internal Medicine
  • Female
  • Drug Interactions
  • Digoxin
  • Coronary Disease
 

Citation

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MLA
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Chen, T. S., & Friedman, H. S. (1980). Alteration of digoxin pharmacokinetics by a single dose of quinidine. JAMA, 244(7), 669–672.
Chen, T. S., and H. S. Friedman. “Alteration of digoxin pharmacokinetics by a single dose of quinidine.JAMA 244, no. 7 (August 15, 1980): 669–72.
Chen TS, Friedman HS. Alteration of digoxin pharmacokinetics by a single dose of quinidine. JAMA. 1980 Aug 15;244(7):669–72.
Chen, T. S., and H. S. Friedman. “Alteration of digoxin pharmacokinetics by a single dose of quinidine.JAMA, vol. 244, no. 7, Aug. 1980, pp. 669–72.
Chen TS, Friedman HS. Alteration of digoxin pharmacokinetics by a single dose of quinidine. JAMA. 1980 Aug 15;244(7):669–672.
Journal cover image

Published In

JAMA

ISSN

0098-7484

Publication Date

August 15, 1980

Volume

244

Issue

7

Start / End Page

669 / 672

Location

United States

Related Subject Headings

  • Time Factors
  • Quinidine
  • Middle Aged
  • Male
  • Humans
  • General & Internal Medicine
  • Female
  • Drug Interactions
  • Digoxin
  • Coronary Disease