Alteration of digoxin pharmacokinetics by a single dose of quinidine.


Journal Article

To determine whether a single dose of quinidine sulfate might alter serum digoxin levels, patients receiving maintenance digoxin therapy who required quinidine had their serum digoxin levels measured after oral administration of digoxin, quinidine, or both. In group 1, digoxin and quinidine were administered orally together; in group 2, digoxin was administered orally alone; and in group 3, quinidine was administered orally, 24 hours after the last dose of digoxin. In group 1, serum digoxin level increased by 2.0+/-0.4 ng/mL (from 1.0+/-0.1 ng/mL), but in group 2, serum digoxin level increased by only 1.0+/-0.1 ng/mL (from 1.0+/-0.1 ng/mL). Group 3 showed no change in serum digoxin concentration. Time of maximum digoxin concentration also occurred earlier when digoxin and quinidine were administered together. Thus, a single dose of quinidine will increase the peak digoxin level when administered together with oral digoxin.

Full Text

Duke Authors

Cited Authors

  • Chen, TS; Friedman, HS

Published Date

  • August 1, 1980

Published In

Volume / Issue

  • 244 / 7

Start / End Page

  • 669 - 672

PubMed ID

  • 6156244

Pubmed Central ID

  • 6156244

Electronic International Standard Serial Number (EISSN)

  • 1538-3598

International Standard Serial Number (ISSN)

  • 0098-7484

Digital Object Identifier (DOI)

  • 10.1001/jama.244.7.669


  • eng