Criteria for termination of phase II chemotherapy for patients with progressive or recurrent brain tumor.

Journal Article (Journal Article)

We report six patients with progressive primary tumors of the brain who had prolonged periods with stable contrast-enhancing CT lesions following initial responses to chemotherapy. Chemotherapy was discontinued after 21 to 36 months, despite the persistence of apparent disease in each patient. PET using (F-18) fluorodeoxyglucose was performed in three patients, revealing hypometabolic lesions. All six patients are alive and well, with no clinical or radiographic evidence of progressive disease at 24 to 57+ months following termination of treatment. The usual criteria for terminating phase II chemotherapy in patients with a recurrent brain tumor are evidence of progressive disease or unacceptable toxicity. However, chemotherapeutic success mandates that these criteria be expanded to include patients whose response following the initiation of phase II treatment is followed by prolonged (greater than 1 year) radiographic and clinical stability. Complete response, ie, disappearance of all evidence of disease, is unusual in patients with recurrent primary brain tumors, even with highly effective therapy. Continued improvement in the therapy of patients with these tumors will allow wider application of these criteria.

Full Text

Duke Authors

Cited Authors

  • Friedman, HS; Schold, SC; Djang, WT; Kurtzberg, J; Longee, DC; Halperin, EC; Falletta, JM; Coleman, RE; Oakes, WJ

Published Date

  • January 1989

Published In

Volume / Issue

  • 39 / 1

Start / End Page

  • 62 - 66

PubMed ID

  • 2783351

International Standard Serial Number (ISSN)

  • 0028-3878

Digital Object Identifier (DOI)

  • 10.1212/wnl.39.1.62


  • eng

Conference Location

  • United States