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Role of glutathione in cellular resistance to alkylating agents.

Publication ,  Journal Article
Colvin, OM; Friedman, HS; Gamcsik, MP; Fenselau, C; Hilton, J
Published in: Adv Enzyme Regul
1993

Both elevated glutathione levels and increased activity of the enzyme glutathione S-transferase have been associated with the resistance of cells to alkylating agents. We have demonstrated that one mechanism of this resistance is the inactivation of the alkylating agents by conjugation with glutathione. This conjugation can be catalyzed by glutathione S-transferase. For the nitrogen mustard agents we have studied, both the spontaneous and enzyme catalyzed reactions proceed through the aziridinium intermediates of the alkylating agents, and the alpha isoenzymes of GST are involved. In a study of cyclophosphamide resistant medulloblastoma cell lines elevated cellular concentrations of glutathione correlated well with the resistance of the cell lines.

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Published In

Adv Enzyme Regul

DOI

ISSN

0065-2571

Publication Date

1993

Volume

33

Start / End Page

19 / 26

Location

England

Related Subject Headings

  • Tumor Cells, Cultured
  • Rabbits
  • Phosphoramide Mustards
  • Mice
  • Melphalan
  • In Vitro Techniques
  • Humans
  • Glutathione Transferase
  • Glutathione
  • Drug Resistance
 

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Colvin, O. M., Friedman, H. S., Gamcsik, M. P., Fenselau, C., & Hilton, J. (1993). Role of glutathione in cellular resistance to alkylating agents. Adv Enzyme Regul, 33, 19–26. https://doi.org/10.1016/0065-2571(93)90006-y
Colvin, O. M., H. S. Friedman, M. P. Gamcsik, C. Fenselau, and J. Hilton. “Role of glutathione in cellular resistance to alkylating agents.Adv Enzyme Regul 33 (1993): 19–26. https://doi.org/10.1016/0065-2571(93)90006-y.
Colvin OM, Friedman HS, Gamcsik MP, Fenselau C, Hilton J. Role of glutathione in cellular resistance to alkylating agents. Adv Enzyme Regul. 1993;33:19–26.
Colvin, O. M., et al. “Role of glutathione in cellular resistance to alkylating agents.Adv Enzyme Regul, vol. 33, 1993, pp. 19–26. Pubmed, doi:10.1016/0065-2571(93)90006-y.
Colvin OM, Friedman HS, Gamcsik MP, Fenselau C, Hilton J. Role of glutathione in cellular resistance to alkylating agents. Adv Enzyme Regul. 1993;33:19–26.
Journal cover image

Published In

Adv Enzyme Regul

DOI

ISSN

0065-2571

Publication Date

1993

Volume

33

Start / End Page

19 / 26

Location

England

Related Subject Headings

  • Tumor Cells, Cultured
  • Rabbits
  • Phosphoramide Mustards
  • Mice
  • Melphalan
  • In Vitro Techniques
  • Humans
  • Glutathione Transferase
  • Glutathione
  • Drug Resistance