Successful therapy for trilateral retinoblastoma.

Journal Article (Journal Article)

Trilateral retinoblastoma, the intracranial malignancy associated with bilateral retinoblastoma, is an uncommon and clinically aggressive malignancy with a uniformly fatal outcome. Three children with newly diagnosed trilateral retinoblastoma were treated with systemic (cyclophosphamide and vincristine) and intrathecal (methotrexate, hydrocortisone, and cytarabine) chemotherapy, as well as craniospinal irradiation (one patient) in addition to therapy of the eye lesions. All three patients have had partial or complete response of the pineal tumors to chemotherapy, with no active disease eight or more years, 33 or more months, and 12 or more months, respectively, after diagnosis of the lesions.

Full Text

Duke Authors

Cited Authors

  • Nelson, SC; Friedman, HS; Oakes, WJ; Halperin, EC; Tien, R; Fuller, GN; Hockenberger, B; Scroggs, MW; Moncino, M; Kurtzberg, J

Published Date

  • July 15, 1992

Published In

Volume / Issue

  • 114 / 1

Start / End Page

  • 23 - 29

PubMed ID

  • 1621782

International Standard Serial Number (ISSN)

  • 0002-9394

Digital Object Identifier (DOI)

  • 10.1016/s0002-9394(14)77408-2


  • eng

Conference Location

  • United States