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Treatment of patients with recurrent primary brain tumors with AZQ.

Publication ,  Journal Article
Schold, SC; Friedman, HS; Bjornsson, TD; Falletta, JM
Published in: Neurology
May 1984

We have evaluated the efficacy of intravenous 2,5-diaziridinyl-3,6-biscarboethoxyamino-1,4-benzoquinone (diaziquone or AZQ, NSC-182986) in the treatment of recurrent primary anaplastic brain tumors. Three of 16 evaluable patients (18.8%) showed clinical and radiographic improvement that permitted discontinuation of corticosteroids, 4 patients (25%) showed either clinical or radiographic improvement and were considered partial responders, and 9 patients (56.2%) showed no effects after two courses of AZQ. The treatment was well tolerated, and hematologic toxicity was mild. Pharmacokinetic studies indicated rapid decay of the parent compound from plasma using two different infusion schedules. These results compare favorably with those obtained using the nitrosoureas or procarbazine as single agents.

Duke Scholars

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

May 1984

Volume

34

Issue

5

Start / End Page

615 / 619

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Middle Aged
  • Medulloblastoma
  • Male
  • Humans
  • Glioma
  • Female
  • Ependymoma
  • Child, Preschool
  • Child
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Schold, S. C., Friedman, H. S., Bjornsson, T. D., & Falletta, J. M. (1984). Treatment of patients with recurrent primary brain tumors with AZQ. Neurology, 34(5), 615–619. https://doi.org/10.1212/wnl.34.5.615
Schold, S. C., H. S. Friedman, T. D. Bjornsson, and J. M. Falletta. “Treatment of patients with recurrent primary brain tumors with AZQ.Neurology 34, no. 5 (May 1984): 615–19. https://doi.org/10.1212/wnl.34.5.615.
Schold SC, Friedman HS, Bjornsson TD, Falletta JM. Treatment of patients with recurrent primary brain tumors with AZQ. Neurology. 1984 May;34(5):615–9.
Schold, S. C., et al. “Treatment of patients with recurrent primary brain tumors with AZQ.Neurology, vol. 34, no. 5, May 1984, pp. 615–19. Pubmed, doi:10.1212/wnl.34.5.615.
Schold SC, Friedman HS, Bjornsson TD, Falletta JM. Treatment of patients with recurrent primary brain tumors with AZQ. Neurology. 1984 May;34(5):615–619.

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

May 1984

Volume

34

Issue

5

Start / End Page

615 / 619

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Middle Aged
  • Medulloblastoma
  • Male
  • Humans
  • Glioma
  • Female
  • Ependymoma
  • Child, Preschool
  • Child