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Vasodilatory state of decompensated cirrhosis: relation to hepatic dysfunction, ascites, and vasoactive substances.

Publication ,  Journal Article
Friedman, HS; Cirillo, N; Schiano, F; Nathan, P; Khan, S; Rosero, H; Vaseghi, M; Sacchi, T; Vasavada, B; Bjornson, L
Published in: Alcohol Clin Exp Res
February 1995

The objective of this study was to determine the relations between the hallmark circulatory finding of decompensated cirrhosis, a reduced systemic vascular resistance (SVR), and the indices of hepatic decompensation, the accumulation of ascites, and the concentrations of various vasoactive substances. At a university-affiliated teaching hospital, eighteen hospitalized patients with cirrhosis and 18 age- and sex-matched healthy subjects were used. This was a case-control study. Measurements included cardiac dimensions and indices derived from echocardiograms and Doppler studies, abdominal ultrasound estimates of ascites, indices of hepatic function, and various serum (S) and urinary (U) substances. Results showed that cirrhotics had increased left atrial and left ventricular dimensions, left ventricular mass, heart rate, cardiac output (CO), transvalvular velocities, and a decreased SVR. SVR was related to hepatic dysfunction, as reflected by an abnormal prothrombin time ratio (r = -0.64, p = 0.006), and also related to overall severity of liver disease as estimated by the Child-Pugh score (r = -0.53, p = 0.044). Although cirrhotics with ascites generally had a reduced SVR, estimates of ascites were directly related to SVR (r = 0.57, p = 0.03) and inversely related to CO (r = -0.53, p = 0.04). Concentrations of S and U digoxin-like immunoreactive substance (DLIS) were also increased, but the concentrations of S glucagon and estradiol were not elevated. The accumulations of S and U DLIS, S glucagon, and S estradiol were all related to hepatic dysfunction.(ABSTRACT TRUNCATED AT 250 WORDS)

Duke Scholars

Published In

Alcohol Clin Exp Res

DOI

ISSN

0145-6008

Publication Date

February 1995

Volume

19

Issue

1

Start / End Page

123 / 129

Location

England

Related Subject Headings

  • Water-Electrolyte Balance
  • Ventricular Function, Left
  • Vasodilation
  • Vascular Resistance
  • Substance Abuse
  • Saponins
  • Middle Aged
  • Male
  • Liver Function Tests
  • Liver Cirrhosis, Alcoholic
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Friedman, H. S., Cirillo, N., Schiano, F., Nathan, P., Khan, S., Rosero, H., … Bjornson, L. (1995). Vasodilatory state of decompensated cirrhosis: relation to hepatic dysfunction, ascites, and vasoactive substances. Alcohol Clin Exp Res, 19(1), 123–129. https://doi.org/10.1111/j.1530-0277.1995.tb01479.x
Friedman, H. S., N. Cirillo, F. Schiano, P. Nathan, S. Khan, H. Rosero, M. Vaseghi, T. Sacchi, B. Vasavada, and L. Bjornson. “Vasodilatory state of decompensated cirrhosis: relation to hepatic dysfunction, ascites, and vasoactive substances.Alcohol Clin Exp Res 19, no. 1 (February 1995): 123–29. https://doi.org/10.1111/j.1530-0277.1995.tb01479.x.
Friedman HS, Cirillo N, Schiano F, Nathan P, Khan S, Rosero H, et al. Vasodilatory state of decompensated cirrhosis: relation to hepatic dysfunction, ascites, and vasoactive substances. Alcohol Clin Exp Res. 1995 Feb;19(1):123–9.
Friedman, H. S., et al. “Vasodilatory state of decompensated cirrhosis: relation to hepatic dysfunction, ascites, and vasoactive substances.Alcohol Clin Exp Res, vol. 19, no. 1, Feb. 1995, pp. 123–29. Pubmed, doi:10.1111/j.1530-0277.1995.tb01479.x.
Friedman HS, Cirillo N, Schiano F, Nathan P, Khan S, Rosero H, Vaseghi M, Sacchi T, Vasavada B, Bjornson L. Vasodilatory state of decompensated cirrhosis: relation to hepatic dysfunction, ascites, and vasoactive substances. Alcohol Clin Exp Res. 1995 Feb;19(1):123–129.
Journal cover image

Published In

Alcohol Clin Exp Res

DOI

ISSN

0145-6008

Publication Date

February 1995

Volume

19

Issue

1

Start / End Page

123 / 129

Location

England

Related Subject Headings

  • Water-Electrolyte Balance
  • Ventricular Function, Left
  • Vasodilation
  • Vascular Resistance
  • Substance Abuse
  • Saponins
  • Middle Aged
  • Male
  • Liver Function Tests
  • Liver Cirrhosis, Alcoholic