Cyclophosphamide for the treatment of progressive low-grade astrocytoma: a Pediatric Oncology Group phase II Study.


Journal Article

PURPOSE: Results of a phase II trial of cyclophosphamide (CPM) for children with progressive low-grade astrocytoma are reported. PATIENTS AND METHODS: Fifteen patients with a median age of 39 months (range, 2 to 71) were included in this study. The tumors of 11 children were located in the optic pathway, hypothalamus, or thalamus. Four courses of intravenous CPM 1.2 g/m2 were administered every 3 weeks during the upfront window portion of this protocol. Subsequently, chemotherapy was to continue with CPM, vincristine, and carboplatin for 2 years. RESULTS: By study design, the first 14 patients were centrally reviewed after completion of the initial 4 CPM courses. Toxicity was primarily hematologic. One patients had a complete response, 8 had stable disease, and 5 had progressive disease (PD). The excessive number of children with PD prompted study closure. CONCLUSION: CPM as used in this protocol showed insufficient activity against astrocytoma to justify further patient accrual.

Full Text

Duke Authors

Cited Authors

  • Kadota, RP; Kun, LE; Langston, JW; Burger, PC; Cohen, ME; Mahoney, DH; Walter, AW; Rodman, JH; Parent, A; Buckley, E; Kepner, JL; Friedman, HS

Published Date

  • May 1999

Published In

Volume / Issue

  • 21 / 3

Start / End Page

  • 198 - 202

PubMed ID

  • 10363852

Pubmed Central ID

  • 10363852

International Standard Serial Number (ISSN)

  • 1077-4114

Digital Object Identifier (DOI)

  • 10.1097/00043426-199905000-00007


  • eng

Conference Location

  • United States