Localisation of [131I]MIBG in nude mice bearing SK-N-SH human neuroblastoma xenografts: effect of specific activity.
Journal Article (Journal Article)
The biodistribution of no-carrier-added (n.c.a.) meta-[131I]iodobenzylguanidine ([131I]MIBG) and that prepared by the standard isotopic exchange method were compared in athymic mice bearing SK-N-SH human neuroblastoma xenografts. No advantage in tumour uptake was observed for the n.c.a. preparation. BALB/c nu/nu mice exhibited lower uptake in highly innervated normal tissues (heart and adrenals) than normal BALB/c mice. In another experiment, the distribution of n.c.a. [131I]MIBG in the absence or presence (3-9 micrograms) of MIBG carrier was determined. At both 4 h and 24 h, the heart uptake was reduced by a factor of 1.5 even at a dose of 3 micrograms MIBG. Tumour uptake was not significantly altered by various amounts of unlabelled MIBG at either time point.
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Duke Authors
Cited Authors
- Vaidyanathan, G; Friedman, HS; Keir, ST; Zalutsky, MR
Published Date
- May 1996
Published In
Volume / Issue
- 73 / 10
Start / End Page
- 1171 - 1177
PubMed ID
- 8630274
Pubmed Central ID
- PMC2074506
International Standard Serial Number (ISSN)
- 0007-0920
Digital Object Identifier (DOI)
- 10.1038/bjc.1996.226
Language
- eng
Conference Location
- England