Skip to main content
Journal cover image

Use of control steady-state serum digoxin levels for predicting serum digoxin concentration after quinidine administration.

Publication ,  Journal Article
Friedman, HS; Chen, TS
Published in: Am Heart J
July 1982

Serum digoxin and/quinidine concentration were measured before and following the institution of quinidine therapy in 11 patients who were receiving maintenance oral digoxin therapy and who required quinidine therapy for suppression of extrasystoles. Steady-state serum digoxin concentrations after quinidine administration were found to correlate well with serum digoxin concentrations before quinidine therapy and with peak serum digoxin concentrations after the first dose of quinidine sulfate, but not with serum quinidine concentrations. Thus steady-state serum digoxin concentration after quinidine (Y) could be estimated from the steady-state serum digoxin concentration before quinidine (X) as expressed by the regression formula Y = 2.6X - 0.6, with Syx2 - 0.21, and r = 0.96 (p less than 0.01). Based on these observations, guidelines for administering digoxin with concomitant quinidine therapy are presented.

Duke Scholars

Published In

Am Heart J

DOI

ISSN

0002-8703

Publication Date

July 1982

Volume

104

Issue

1

Start / End Page

72 / 76

Location

United States

Related Subject Headings

  • Quinidine
  • Middle Aged
  • Male
  • Humans
  • Female
  • Drug Interactions
  • Dose-Response Relationship, Drug
  • Digoxin
  • Cardiovascular System & Hematology
  • Cardiac Complexes, Premature
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Friedman, H. S., & Chen, T. S. (1982). Use of control steady-state serum digoxin levels for predicting serum digoxin concentration after quinidine administration. Am Heart J, 104(1), 72–76. https://doi.org/10.1016/0002-8703(82)90643-3
Friedman, H. S., and T. S. Chen. “Use of control steady-state serum digoxin levels for predicting serum digoxin concentration after quinidine administration.Am Heart J 104, no. 1 (July 1982): 72–76. https://doi.org/10.1016/0002-8703(82)90643-3.
Friedman, H. S., and T. S. Chen. “Use of control steady-state serum digoxin levels for predicting serum digoxin concentration after quinidine administration.Am Heart J, vol. 104, no. 1, July 1982, pp. 72–76. Pubmed, doi:10.1016/0002-8703(82)90643-3.
Journal cover image

Published In

Am Heart J

DOI

ISSN

0002-8703

Publication Date

July 1982

Volume

104

Issue

1

Start / End Page

72 / 76

Location

United States

Related Subject Headings

  • Quinidine
  • Middle Aged
  • Male
  • Humans
  • Female
  • Drug Interactions
  • Dose-Response Relationship, Drug
  • Digoxin
  • Cardiovascular System & Hematology
  • Cardiac Complexes, Premature