Comparison of serial PET and MRI scans in a pediatric patient with a brainstem glioma.

Journal Article (Journal Article)

Profound clinical deficits may be associated with insults to the brainstem, making management of patients with brainstem gliomas very complex. Small changes in the radiographic appearance of a brainstem tumor may be associated with significant clinical deterioration. Furthermore, both magnetic resonance imaging and computed tomography are frequently unable to differentiate between therapy-related tissue reactions and progressive tumor. Two clinical scenarios particularly difficult to resolve include: (1) transient radiographic and clinical deterioration following hyperfractionated radiotherapy, and (2) clinical deterioration in a patient who has failed initial therapy, but has stable radiographic findings following a second therapy. We report a child with a pontine glioma whose tumor progression was demonstrated more convincingly with a 18F-deoxyglucose positron emission scan than with magnetic resonance imaging. PET scans may be helpful in confirming that tumor progression is responsible for clinical deterioration in a patient whose MRI scans remain stable.

Full Text

Duke Authors

Cited Authors

  • Bruggers, CS; Friedman, HS; Fuller, GN; Tien, RD; Marks, LB; Halperin, EC; Hockenberger, B; Oakes, WJ; Hoffman, JM

Published Date

  • 1993

Published In

Volume / Issue

  • 21 / 4

Start / End Page

  • 301 - 306

PubMed ID

  • 8469227

Pubmed Central ID

  • 8469227

International Standard Serial Number (ISSN)

  • 0098-1532

Digital Object Identifier (DOI)

  • 10.1002/mpo.2950210414


  • eng

Conference Location

  • United States