Topotecan for the treatment of recurrent or progressive central nervous system tumors - a pediatric oncology group phase II study.

Journal Article (Clinical Trial;Journal Article)

Topotecan was studied as a 72 h infusion given every 3 weeks. Treatment began at a dose of 1.0 mg/m2/day and was increased to 1.25 mg/m2/day after the first 6 patients tolerated this higher dose without excessive toxicities. Eighty-eight evaluable children were accrued in 6 strata. There were no complete nor partial responses. Twenty subjects had stable disease (astrocytoma 5/11, malignant glioma 5/13, medulloblastoma 0/12, brain stem tumor 4/19, ependymoma 5/17, and miscellaneous histologies 1/16). Two patients (astrocytoma, ependymoma) completed the maximum 18 topotecan courses. The remaining 68 children developed progressive disease within 2 months. Myelosuppression was the main toxicity. Grade 4 leukopenia, neutropenia, anemia, and thrombocytopenia were observed in 18, 32, 5, and 23 participants, respectively. It was concluded that topotecan as given according to this schedule showed insufficient activity to promote it to frontline protocol usage.

Full Text

Duke Authors

Cited Authors

  • Kadota, RP; Stewart, CF; Horn, M; Kuttesch, JF; Burger, PC; Kepner, JL; Kun, LE; Friedman, HS; Heideman, RL

Published Date

  • May 1999

Published In

Volume / Issue

  • 43 / 1

Start / End Page

  • 43 - 47

PubMed ID

  • 10448870

Pubmed Central ID

  • 10448870

International Standard Serial Number (ISSN)

  • 0167-594X

Digital Object Identifier (DOI)

  • 10.1023/a:1006294102611


  • eng

Conference Location

  • United States