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Cardiac function in alcohol-associated systemic hypertension.

Publication ,  Journal Article
Friedman, HS; Vasavada, BC; Malec, AM; Hassan, KK; Shah, A; Siddiqui, S
Published in: Am J Cardiol
February 1, 1986

The pathogenesis of alcohol cardiomyopathy is obscure. Because systemic hypertension is observed in one-third of alcoholics, the relation of this finding to left ventricular (LV) function was analyzed in 66 alcoholics (26 with a blood pressure of 160/95 mm Hg or higher) 4 to 5 days after alcohol withdrawal. Hypertensive alcoholics had a more abnormal ratio of preejection period/LV ejection time (PEP/ET) (0.398 +/- 0.01 vs 0.35 +/- 0.01, p less than 0.02) than normotensive alcoholics (matched normal 0.290 +/- 0.01). Hypertensive alcoholics (transitory hypertension) with blood pressures of 120/80 mm Hg or less at time of study also had more abnormal PEP/LVET than matched normotensive alcoholics (0.415 +/- 0.03 vs 0.331 +/- 0.01, p less than 0.05). In both hypertensive (77 +/- 6 dynes/cm2 X 10(3)) and normotensive alcoholics (67 +/- 4 dynes/cm2 X 10(3) LV stress was elevated (normal 46 +/- 3 dynes/cm2 X 10(3), both p less than 0.02). However, LV mass was not increased (hypertensive 96 +/- 4 g/m2; vs normotensive 100 +/- 4 g/m2; (normal 92 +/- 5 g/m2), resulting in a markedly increased stress to mass ratio (hypertensive 0.8 +/- 0.06; Normal 0.05 +/- 0.05, p less than 0.02). Hypertensive alcoholics also had LV "hyperfunction," with an increased stress/LV end-systolic volume ratio (1.7 +/- 0.1 vs 1.3 +/- 0.1 dynes/cm2 X 10(3)/ml, p less than 0.02). Thus, hypertensive alcoholics, even those with transitory hypertension, have more abnormal cardiac function than normotensive alcoholics. Presence of hypertension with hyperdynamic LV features may be a prelude to heart failure.

Duke Scholars

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

February 1, 1986

Volume

57

Issue

4

Start / End Page

227 / 231

Location

United States

Related Subject Headings

  • Stroke Volume
  • Risk
  • Myocardial Contraction
  • Male
  • Hypertension
  • Humans
  • Heart Rate
  • Heart
  • Electrocardiography
  • Echocardiography
 

Citation

APA
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ICMJE
MLA
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Friedman, H. S., Vasavada, B. C., Malec, A. M., Hassan, K. K., Shah, A., & Siddiqui, S. (1986). Cardiac function in alcohol-associated systemic hypertension. Am J Cardiol, 57(4), 227–231. https://doi.org/10.1016/0002-9149(86)90896-9
Friedman, H. S., B. C. Vasavada, A. M. Malec, K. K. Hassan, A. Shah, and S. Siddiqui. “Cardiac function in alcohol-associated systemic hypertension.Am J Cardiol 57, no. 4 (February 1, 1986): 227–31. https://doi.org/10.1016/0002-9149(86)90896-9.
Friedman HS, Vasavada BC, Malec AM, Hassan KK, Shah A, Siddiqui S. Cardiac function in alcohol-associated systemic hypertension. Am J Cardiol. 1986 Feb 1;57(4):227–31.
Friedman, H. S., et al. “Cardiac function in alcohol-associated systemic hypertension.Am J Cardiol, vol. 57, no. 4, Feb. 1986, pp. 227–31. Pubmed, doi:10.1016/0002-9149(86)90896-9.
Friedman HS, Vasavada BC, Malec AM, Hassan KK, Shah A, Siddiqui S. Cardiac function in alcohol-associated systemic hypertension. Am J Cardiol. 1986 Feb 1;57(4):227–231.
Journal cover image

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

February 1, 1986

Volume

57

Issue

4

Start / End Page

227 / 231

Location

United States

Related Subject Headings

  • Stroke Volume
  • Risk
  • Myocardial Contraction
  • Male
  • Hypertension
  • Humans
  • Heart Rate
  • Heart
  • Electrocardiography
  • Echocardiography