Osteoblastic metastases from astrocytomas: a report of two cases.

Journal Article (Journal Article)

The spread of primary central nervous system (CNS) neoplasms beyond the confines of the neuraxis is a relatively uncommon observation. Extraneural metastases involving bone are quite rare, and have been observed almost exclusively in cases of medulloblastoma, high-grade (III-IV) astrocytoma, and glioblastoma multiforme. To date there has been only one case reported of bone metastasis from a "well-differentiated" astrocytoma. We now report two cases of astrocytoma in children with diffuse osteoblastic metastases and a fulminant clinical course. These cases demonstrate that due to the potential morphologic heterogeneity of these neoplasms, an initial biopsy diagnosis of low-grade astrocytoma does not always imply a benign clinical course.

Full Text

Duke Authors

Cited Authors

  • Longee, DC; Friedman, HS; Phillips, PC; Burger, PC; Oakes, WJ; Heffez, D; Wharam, M; Strauss, L; Fuller, GN; Schold, SC

Published Date

  • 1991

Published In

Volume / Issue

  • 19 / 4

Start / End Page

  • 318 - 324

PubMed ID

  • 2056977

Pubmed Central ID

  • 2056977

International Standard Serial Number (ISSN)

  • 0098-1532

Digital Object Identifier (DOI)

  • 10.1002/mpo.2950190419


  • eng

Conference Location

  • United States