Treatment of trilateral retinoblastoma with vincristine and cyclophosphamide.

Journal Article (Journal Article)

Current therapy for patients with trilateral retinoblastoma, consisting primarily of surgical intervention and radiotherapy, has resulted in no long-term survivors. The use of adjuvant chemotherapy has not improved this outcome. After observing a tumor response to cyclophosphamide in a patient with suprasellar retinoblastoma, we treated a subsequent patient with trilateral retinoblastoma with both vincristine and cyclophosphamide. Objective tumor regression resulted. Although the tumor ultimately progressed in both patients, these findings suggest that vincristine and cyclophosphamide are active in patients with intracranial (trilateral) retinoblastoma.

Full Text

Duke Authors

Cited Authors

  • Malik, RK; Friedman, HS; Djang, WT; Falletta, JM; Buckley, E; Kurtzberg, J; Kinney, TR; Stine, K; Chaffee, S; Hayes, J

Published Date

  • November 15, 1986

Published In

Volume / Issue

  • 102 / 5

Start / End Page

  • 650 - 656

PubMed ID

  • 3777087

International Standard Serial Number (ISSN)

  • 0002-9394

Digital Object Identifier (DOI)

  • 10.1016/0002-9394(86)90540-4


  • eng

Conference Location

  • United States