Ascites as a marker for the hyperdynamic heart of Laennec's cirrhosis.

Journal Article (Journal Article)

UNLABELLED: The purpose of this study was to determine the relation of the circulatory findings of cirrhosis to hepatic decompensation. Twenty individuals with biopsy-proven cirrhosis and 15 aged-matched controls underwent echocardiographic evaluation of cardiac function. Cardiac dimensions and indices derived from echocardiograms were related to various measures of liver decompensation. Cirrhotics had a higher heart rate, left ventricular end-diastolic volume, left ventricular ejection fraction, and cardiac output and a lower mean blood pressure and peripheral resistance than aged-matched subjects. On multiple regression analyses mean blood pressure, peripheral resistance, and cardiac output were all found to be related to estimates of ascites. Also, cirrhotics with ascites had a lower peripheral resistance than those without this finding. CONCLUSION: In clinically stable patients with cirrhosis, the presence of ascites indicates an intense vasodilatory state with a hyperdynamic circulation.

Full Text

Duke Authors

Cited Authors

  • Friedman, HS; Fernando, H

Published Date

  • October 1992

Published In

Volume / Issue

  • 16 / 5

Start / End Page

  • 968 - 970

PubMed ID

  • 1443437

International Standard Serial Number (ISSN)

  • 0145-6008

Digital Object Identifier (DOI)

  • 10.1111/j.1530-0277.1992.tb01902.x


  • eng

Conference Location

  • England