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Radiotherapy in pediatric medulloblastoma: quality assessment of Pediatric Oncology Group Trial 9031.

Publication ,  Journal Article
Miralbell, R; Fitzgerald, TJ; Laurie, F; Kessel, S; Glicksman, A; Friedman, HS; Urie, M; Kepner, JL; Zhou, T; Chen, Z; Barnes, P; Kun, L; Tarbell, NJ
Published in: Int J Radiat Oncol Biol Phys
April 1, 2006

PURPOSE: To evaluate the potential influence of radiotherapy quality on survival in high-risk pediatric medulloblastoma patients. METHODS AND MATERIALS: Trial 9031 of the Pediatric Oncology Group (POG) aimed to study the relative benefit of cisplatin and etoposide randomization of high-risk patients with medulloblastoma to preradiotherapy vs. postradiotherapy treatment. Two-hundred and ten patients were treated according to protocol guidelines and were eligible for the present analysis. Treatment volume (whole brain, spine, posterior fossa, and primary tumor bed) and dose prescription deviations were assessed for each patient. An analysis of first site of failure was undertaken. Event-free and overall survival rates were calculated. A log-rank test was used to determine the significance of potential survival differences between patients with and without major deviations in the radiotherapy procedure. RESULTS: Of 160 patients who were fully evaluable for all treatment quality parameters, 91 (57%) had 1 or more major deviations in their treatment schedule. Major deviations by treatment site were brain (26%), spinal (7%), posterior fossa (40%), and primary tumor bed (17%). Major treatment volume or total dose deviations did not significantly influence overall and event-free survival. CONCLUSIONS: Despite major treatment deviations in more than half of fully evaluable patients, underdosage or treatment volume misses were not associated with a worse event-free or overall survival.

Duke Scholars

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

April 1, 2006

Volume

64

Issue

5

Start / End Page

1325 / 1330

Location

United States

Related Subject Headings

  • Survival Rate
  • Spinal Neoplasms
  • Radiotherapy
  • Quality Assurance, Health Care
  • Oncology & Carcinogenesis
  • Medulloblastoma
  • Infratentorial Neoplasms
  • Humans
  • Etoposide
  • Cranial Irradiation
 

Citation

APA
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ICMJE
MLA
NLM
Miralbell, R., Fitzgerald, T. J., Laurie, F., Kessel, S., Glicksman, A., Friedman, H. S., … Tarbell, N. J. (2006). Radiotherapy in pediatric medulloblastoma: quality assessment of Pediatric Oncology Group Trial 9031. Int J Radiat Oncol Biol Phys, 64(5), 1325–1330. https://doi.org/10.1016/j.ijrobp.2005.11.002
Miralbell, Raymond, T. J. Fitzgerald, Fran Laurie, Sandy Kessel, Arvin Glicksman, Henry S. Friedman, Marcia Urie, et al. “Radiotherapy in pediatric medulloblastoma: quality assessment of Pediatric Oncology Group Trial 9031.Int J Radiat Oncol Biol Phys 64, no. 5 (April 1, 2006): 1325–30. https://doi.org/10.1016/j.ijrobp.2005.11.002.
Miralbell R, Fitzgerald TJ, Laurie F, Kessel S, Glicksman A, Friedman HS, et al. Radiotherapy in pediatric medulloblastoma: quality assessment of Pediatric Oncology Group Trial 9031. Int J Radiat Oncol Biol Phys. 2006 Apr 1;64(5):1325–30.
Miralbell, Raymond, et al. “Radiotherapy in pediatric medulloblastoma: quality assessment of Pediatric Oncology Group Trial 9031.Int J Radiat Oncol Biol Phys, vol. 64, no. 5, Apr. 2006, pp. 1325–30. Pubmed, doi:10.1016/j.ijrobp.2005.11.002.
Miralbell R, Fitzgerald TJ, Laurie F, Kessel S, Glicksman A, Friedman HS, Urie M, Kepner JL, Zhou T, Chen Z, Barnes P, Kun L, Tarbell NJ. Radiotherapy in pediatric medulloblastoma: quality assessment of Pediatric Oncology Group Trial 9031. Int J Radiat Oncol Biol Phys. 2006 Apr 1;64(5):1325–1330.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

April 1, 2006

Volume

64

Issue

5

Start / End Page

1325 / 1330

Location

United States

Related Subject Headings

  • Survival Rate
  • Spinal Neoplasms
  • Radiotherapy
  • Quality Assurance, Health Care
  • Oncology & Carcinogenesis
  • Medulloblastoma
  • Infratentorial Neoplasms
  • Humans
  • Etoposide
  • Cranial Irradiation