Sodium etidronate in the treatment of Paget's disease of bone. A study of long-term results.
Published
Journal Article (Academic article)
Subjects (109) with symptomatic Paget's disease of bone were treated with 5, 10, or 20 mg of sodium etidronate (EHDP)/kg body weight - day for 6 to 24 months. Significant decreases in serum alkaline phosphatase and urinary hydroxyproline were noted after 6 months of therapy; no significant further improvement resulted after prolonged therapy. Some patients maintained biochemical remission after withdrawal of EHDP but others showed a relapse, related primarily to the pretreatment severity. Clinical improvement was noted in 61% of the patients. Similar findings were seen after a second course of EHDP. No side-effects were noted in patients treated with 5 mg of EHDP/kg body weight - day. In patients treated with 10 or 20 mg of EHDP/kg body weight - day, severe diarrhea, bone pain, and nontraumatic fractures were noted in 3, 13, and 12 patients respectively. Quantitative histomorphometry showed mineralization delay in patients receiving 10 or 20 mg of EHDP/kg body weight - day but not in those receiving 5 mg/kg body weight - day. Five milligrams of EHDP/kg body weight - day was effective and appears to be safer than the higher doses.
Duke Authors
Cited Authors
- Khairi, MR; Altman, RD; DeRosa, GP; Zimmermann, J; Schenk, RK; Johnston, CC
Published Date
- December 1, 1977
Published In
Volume / Issue
- 87 / 6
Start / End Page
- 656 - 663
International Standard Serial Number (ISSN)
- 0003-4819
Conference Location
- united states