Reversing nerve-graft polarity in a rat model: the effect on function.

Journal Article (Journal Article)

To evaluate the effect of nerve-graft polarity on function, a 1-cm segment of sciatic nerve was excised and reoriented in three groups of 20 adult Sprague-Dawley rats. In one group, the nerve was cut and anastomosed in the original orientation to act as a control. In the second group, the nerve-graft polarity was reversed 180 degrees. The final group underwent reversal of polarity 180 degrees and was rotated 180 degrees, (i.e., the posterior tibial nerve fascicles proximally were opposite to the peroneal nerve fascicles distally). Functional recovery was evaluated using Bain's modification of de Medinaceli's sciatic functional index (SFI). Rat-track analysis was performed over a 120-day period. Histologic correlation was also performed at the time of sacrifice. From our study, we concluded that reversing nerve-graft polarity, with or without rotation, does not influence subsequent function in this model.

Full Text

Duke Authors

Cited Authors

  • Sotereanos, DG; Seaber, AV; Urbaniak, JR; Spiegel, DA; Sotereanos, D; Anthony, DC

Published Date

  • July 1992

Published In

Volume / Issue

  • 8 / 4

Start / End Page

  • 303 - 307

PubMed ID

  • 1629808

International Standard Serial Number (ISSN)

  • 0743-684X

Digital Object Identifier (DOI)

  • 10.1055/s-2007-1006712


  • eng

Conference Location

  • United States