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Role of nitric oxide in vasodilation in upstream muscle during intermittent pneumatic compression.

Publication ,  Journal Article
Chen, L-E; Liu, K; Qi, W-N; Joneschild, E; Tan, X; Seaber, AV; Stamler, JS; Urbaniak, JR
Published in: J Appl Physiol (1985)
February 2002

This study investigated the dosage effects of nitric oxide synthase (NOS) inhibitor N(G)-monomethyl-L-arginine (L-NMMA) on intermittent pneumatic compression (IPC)-induced vasodilation in uncompressed upstream muscle and the effects of IPC on endothelial NOS (eNOS) expression in upstream muscle. After L-NMMA infusion, mean arterial pressure increased by 5% from baseline (99.5 +/- 18.7 mmHg; P < 0.05). Heart rate and respiratory rate were not significantly affected. One-hour IPC application on legs induced a 10% dilation from baseline in 10- to 20-microm arterioles and a 10-20% dilation in 21- to 40 microm arterioles and 41- to 70-microm arteries in uncompressed cremaster muscle. IPC-induced vasodilation was dose dependently reduced, abolished, or even reversed by concurrently infused L-NMMA. Moreover, expression of eNOS mRNA in uncompressed cremaster muscle was upregulated to 2 and 2.5 times normal at the end of 1- and 5-h IPC on legs, respectively, and the expression of eNOS protein was upregulated to 1.8 times normal. These increases returned to baseline level after cessation of IPC. The results suggest that eNOS plays an important role in regulating the microcirculation in upstream muscle during IPC.

Duke Scholars

Published In

J Appl Physiol (1985)

DOI

ISSN

8750-7587

Publication Date

February 2002

Volume

92

Issue

2

Start / End Page

559 / 566

Location

United States

Related Subject Headings

  • omega-N-Methylarginine
  • Vasodilation
  • Reference Values
  • Rats, Sprague-Dawley
  • Rats
  • RNA, Messenger
  • Pressure
  • Physiology
  • Nitric Oxide Synthase Type III
  • Nitric Oxide Synthase
 

Citation

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Chen, L.-E., Liu, K., Qi, W.-N., Joneschild, E., Tan, X., Seaber, A. V., … Urbaniak, J. R. (2002). Role of nitric oxide in vasodilation in upstream muscle during intermittent pneumatic compression. J Appl Physiol (1985), 92(2), 559–566. https://doi.org/10.1152/japplphysiol.00365.2001
Chen, Long-En, Kang Liu, Wen-Ning Qi, Elizabeth Joneschild, Xiangling Tan, Anthony V. Seaber, Jonathan S. Stamler, and James R. Urbaniak. “Role of nitric oxide in vasodilation in upstream muscle during intermittent pneumatic compression.J Appl Physiol (1985) 92, no. 2 (February 2002): 559–66. https://doi.org/10.1152/japplphysiol.00365.2001.
Chen L-E, Liu K, Qi W-N, Joneschild E, Tan X, Seaber AV, et al. Role of nitric oxide in vasodilation in upstream muscle during intermittent pneumatic compression. J Appl Physiol (1985). 2002 Feb;92(2):559–66.
Chen, Long-En, et al. “Role of nitric oxide in vasodilation in upstream muscle during intermittent pneumatic compression.J Appl Physiol (1985), vol. 92, no. 2, Feb. 2002, pp. 559–66. Pubmed, doi:10.1152/japplphysiol.00365.2001.
Chen L-E, Liu K, Qi W-N, Joneschild E, Tan X, Seaber AV, Stamler JS, Urbaniak JR. Role of nitric oxide in vasodilation in upstream muscle during intermittent pneumatic compression. J Appl Physiol (1985). 2002 Feb;92(2):559–566.

Published In

J Appl Physiol (1985)

DOI

ISSN

8750-7587

Publication Date

February 2002

Volume

92

Issue

2

Start / End Page

559 / 566

Location

United States

Related Subject Headings

  • omega-N-Methylarginine
  • Vasodilation
  • Reference Values
  • Rats, Sprague-Dawley
  • Rats
  • RNA, Messenger
  • Pressure
  • Physiology
  • Nitric Oxide Synthase Type III
  • Nitric Oxide Synthase