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Coagulation changes in elective surgery and trauma.

Publication ,  Journal Article
Seyfer, AE; Seaber, AV; Dombrose, FA; Urbaniak, JR
Published in: Ann Surg
February 1981

Although antithrombin-3 (AT-3), a naturally-occurring inhibitor of thrombin, has been associated with a variety of thrombotic disorders, it has been studied in surgery and trauma. Three groups of patients were studied: Group I (20 patients) who underwent elective surgery; Group II (ten patients) who sustained moderate trauma: Group III (ten patients) who sustained severe trauma. Hypercoagulability panels were run preoperatively, intraoperatively, and postoperatively. Nine units of banked blood were also tested. The coagulation pattern changed during the stress, becoming hypercoagulable in proportion to the stress endured by the patient. In the severe trauma group, AT-3 fell significantly (p less than or equal to 0.002) in all patients, indicating extreme hypercoagulability. Three of these patients sustained thrombosis and loss of the involved extremity. The banked blood was found to be hypercoagulable. It appears that patients who sustain severe trauma, have multiple transfusions, and major operative procedures are at increased risk of developing postoperative thrombotic complications, including loss of limb.

Duke Scholars

Published In

Ann Surg

DOI

ISSN

0003-4932

Publication Date

February 1981

Volume

193

Issue

2

Start / End Page

210 / 213

Location

United States

Related Subject Headings

  • Wounds and Injuries
  • Thrombin Time
  • Surgical Procedures, Operative
  • Surgery
  • Prothrombin Time
  • Plasminogen
  • Middle Aged
  • Humans
  • Child, Preschool
  • Child
 

Citation

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Seyfer, A. E., Seaber, A. V., Dombrose, F. A., & Urbaniak, J. R. (1981). Coagulation changes in elective surgery and trauma. Ann Surg, 193(2), 210–213. https://doi.org/10.1097/00000658-198102000-00015
Seyfer, A. E., A. V. Seaber, F. A. Dombrose, and J. R. Urbaniak. “Coagulation changes in elective surgery and trauma.Ann Surg 193, no. 2 (February 1981): 210–13. https://doi.org/10.1097/00000658-198102000-00015.
Seyfer AE, Seaber AV, Dombrose FA, Urbaniak JR. Coagulation changes in elective surgery and trauma. Ann Surg. 1981 Feb;193(2):210–3.
Seyfer, A. E., et al. “Coagulation changes in elective surgery and trauma.Ann Surg, vol. 193, no. 2, Feb. 1981, pp. 210–13. Pubmed, doi:10.1097/00000658-198102000-00015.
Seyfer AE, Seaber AV, Dombrose FA, Urbaniak JR. Coagulation changes in elective surgery and trauma. Ann Surg. 1981 Feb;193(2):210–213.

Published In

Ann Surg

DOI

ISSN

0003-4932

Publication Date

February 1981

Volume

193

Issue

2

Start / End Page

210 / 213

Location

United States

Related Subject Headings

  • Wounds and Injuries
  • Thrombin Time
  • Surgical Procedures, Operative
  • Surgery
  • Prothrombin Time
  • Plasminogen
  • Middle Aged
  • Humans
  • Child, Preschool
  • Child