Morphologic and morphometric analyses of rat femoral arteries after crush injury.


Journal Article

Replantation after crush amputation has a relatively low success rate. An arterial crush injury was produced in rats under a range of pressure (8.5 to 2,551 g/mm2) and durations (10 to 60 minutes). The degrees of vessel injury and thrombus formation were evaluated as functions of both crush force and duration, and the healing process was followed for 8 weeks. Crushing resulted in morphologic damage to the arterial wall but did not impair patency. Damage was directly proportional to crush pressure and duration. Intimal denudation caused flat platelet adhesion but no thrombus formation or thrombosis. Re-endothelialization was completed by 2 weeks. Intimal hyperplasia appeared at 1 week and consisted of endothelia in the most luminal layers and smooth muscle in the deeper layers. the internal elastic lamina was intact in all specimens and was thought to minimize platelet aggregation on the arterial wall after denudation of the intima.

Full Text

Duke Authors

Cited Authors

  • Chen, LE; Seaber, AV; Glisson, RR; Mikat, EM; Urbaniak, JR

Published Date

  • 1991

Published In

Volume / Issue

  • 12 / 6

Start / End Page

  • 402 - 411

PubMed ID

  • 1766356

Pubmed Central ID

  • 1766356

International Standard Serial Number (ISSN)

  • 0738-1085

Digital Object Identifier (DOI)

  • 10.1002/micr.1920120607


  • eng

Conference Location

  • United States