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Inhibition of vessel allograft rejection by endothelial removal. Morphologic and ultrastructural changes.

Publication ,  Journal Article
Galumbeck, MA; Sanfilippo, FP; Hagen, PO; Seaber, AV; Urbaniak, JR
Published in: Ann Surg
December 1987

The vascular endothelium plays an important and complex role in vascular allograft rejection. Antigens expressed by the endothelium can act to promote and be the target of rejection reactions, which often lead to thrombosis and ischemic necrosis of the allograft. In this study, segments of femoral artery and femoral vein with or without endothelium were grafted between allogenic or autologous control rats. Immunocompetent Lewis (RT1(1] recipient rats were randomly selected for groups (N = 14 for each) receiving the following: ACI- (RT1a) allografts with intact endothelium, allografts with endothelium removed before operation, autografts with endothelium, and autografts with endothelium removed. Rejection was assessed by graft patency as well as morphologic and ultrastructural changes. At 5 days, the allografts with intact endothelium were totally occluded, whereas allografts without endothelium remained patent, as did autologous control grafts with or without endothelium. Two additional groups (N = 14 each) receiving the de-endothelialized allografts or autografts were examined at 120 days after operation, revealing that grafts in both groups were still patent and had been re-endothelialized. These findings indicate that physical removal of vascular endothelium may depress vessel allograft rejection without immunosuppressive therapy.

Duke Scholars

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Published In

Ann Surg

DOI

ISSN

0003-4932

Publication Date

December 1987

Volume

206

Issue

6

Start / End Page

757 / 764

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Transplantation, Autologous
  • Surgery
  • Rats, Inbred Lew
  • Rats, Inbred ACI
  • Rats
  • Microscopy, Electron
  • Male
  • Lymphocytes
  • Graft Rejection
 

Citation

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ICMJE
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Galumbeck, M. A., Sanfilippo, F. P., Hagen, P. O., Seaber, A. V., & Urbaniak, J. R. (1987). Inhibition of vessel allograft rejection by endothelial removal. Morphologic and ultrastructural changes. Ann Surg, 206(6), 757–764. https://doi.org/10.1097/00000658-198712000-00012
Galumbeck, M. A., F. P. Sanfilippo, P. O. Hagen, A. V. Seaber, and J. R. Urbaniak. “Inhibition of vessel allograft rejection by endothelial removal. Morphologic and ultrastructural changes.Ann Surg 206, no. 6 (December 1987): 757–64. https://doi.org/10.1097/00000658-198712000-00012.
Galumbeck MA, Sanfilippo FP, Hagen PO, Seaber AV, Urbaniak JR. Inhibition of vessel allograft rejection by endothelial removal. Morphologic and ultrastructural changes. Ann Surg. 1987 Dec;206(6):757–64.
Galumbeck, M. A., et al. “Inhibition of vessel allograft rejection by endothelial removal. Morphologic and ultrastructural changes.Ann Surg, vol. 206, no. 6, Dec. 1987, pp. 757–64. Pubmed, doi:10.1097/00000658-198712000-00012.
Galumbeck MA, Sanfilippo FP, Hagen PO, Seaber AV, Urbaniak JR. Inhibition of vessel allograft rejection by endothelial removal. Morphologic and ultrastructural changes. Ann Surg. 1987 Dec;206(6):757–764.

Published In

Ann Surg

DOI

ISSN

0003-4932

Publication Date

December 1987

Volume

206

Issue

6

Start / End Page

757 / 764

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Transplantation, Autologous
  • Surgery
  • Rats, Inbred Lew
  • Rats, Inbred ACI
  • Rats
  • Microscopy, Electron
  • Male
  • Lymphocytes
  • Graft Rejection