Relief of blood-induced arterial vasospasm by pharmacologic solutions.

Journal Article (Journal Article)

A partially amputated rat hind limb model was used to evaluate the potency of 1 percent, 2 percent, and 20 percent Xylocaine, 0.3 percent papaverine, and normal saline in both the treatment and prevention of blood-induced arterial spasm. Direct application of blood to the femoral artery was shown to produce a 60 percent reduction in limb perfusion. The 0.3 percent papaverine and 20 percent Xylocaine solutions were statistically superior to normal saline and the lower Xylocaine concentrations in their ability to relieve the blood-induced vasospasm and prevent further spasm. Normal saline, 1 percent Xylocaine, and 2 percent Xylocaine showed no preventive effect against blood-induced spasm. These findings emphasize the importance of good hemostasis in microsurgery, and simplify the choice of an effective spasmolytic agent.

Full Text

Duke Authors

Cited Authors

  • Hou, SM; Seaber, AV; Urbaniak, JR

Published Date

  • January 1987

Published In

Volume / Issue

  • 3 / 2

Start / End Page

  • 147 - 151

PubMed ID

  • 3560041

International Standard Serial Number (ISSN)

  • 0743-684X

Digital Object Identifier (DOI)

  • 10.1055/s-2007-1006978


  • eng

Conference Location

  • United States