Combined effect of acute denervation and ischemia on the microcirculation of skeletal muscle.

Journal Article (Journal Article)

Using direct in vivo videomicroscopy and a fluorescein dye technique, reperfusion injury after 3 h of ischemia was studied in the acutely denervated cremaster muscle of the rat. Compared with normally innervated controls, ischemia-induced reperfusion injury was more severe in the denervated group and included a delay of blood flow recovery, vortex formation, edema, hemorrhage, and vessel spasm. Vessel size was reduced at the arteriole and small artery level, and there was a decrease of reactive hyperemia. The injury mechanism may be related to a loss of active vasomotion and vascular response to vasoactive substances after denervation. The results suggest that shortening the ischemia time of denervated tissues may reduce ischemia-induced reperfusion injury. Similarly, given the same ischemia time, improved tissue reperfusion may be expected if the nerve supply is maintained.

Full Text

Duke Authors

Cited Authors

  • Chen, LE; Seaber, AV; Urbaniak, JR

Published Date

  • January 1992

Published In

Volume / Issue

  • 10 / 1

Start / End Page

  • 112 - 120

PubMed ID

  • 1727931

International Standard Serial Number (ISSN)

  • 0736-0266

Digital Object Identifier (DOI)

  • 10.1002/jor.1100100114


  • eng

Conference Location

  • United States