Combined effect of acute denervation and ischemia on the microcirculation of skeletal muscle.
Journal Article (Journal Article)
Using direct in vivo videomicroscopy and a fluorescein dye technique, reperfusion injury after 3 h of ischemia was studied in the acutely denervated cremaster muscle of the rat. Compared with normally innervated controls, ischemia-induced reperfusion injury was more severe in the denervated group and included a delay of blood flow recovery, vortex formation, edema, hemorrhage, and vessel spasm. Vessel size was reduced at the arteriole and small artery level, and there was a decrease of reactive hyperemia. The injury mechanism may be related to a loss of active vasomotion and vascular response to vasoactive substances after denervation. The results suggest that shortening the ischemia time of denervated tissues may reduce ischemia-induced reperfusion injury. Similarly, given the same ischemia time, improved tissue reperfusion may be expected if the nerve supply is maintained.
- Chen, LE; Seaber, AV; Urbaniak, JR
- January 1992
Volume / Issue
- 10 / 1
Start / End Page
- 112 - 120
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)
- United States