Intravascular thrombosis in skeletal muscle microcirculation after ischemia.


Journal Article

This study was undertaken to elucidate the role of thrombosis in blood vessels less than 0.1 mm in diameter in skeletal muscle after an ischemic episode. Capillaries were examined after normothermic ischemia using intravital video microscopy of the cremaster muscle of an anesthetized rat. Histologic sections of the cremaster muscle and silicone rubber intravascular casts were also analyzed. Our model demonstrates that, after 3 hours of warm ischemia, up to two-thirds of capillaries are clotted, as is most of the venous system. Our findings also indicate that capillaries may reopen during 30 minutes of reperfusion. These findings suggest that ischemia may cause thrombosis in the microvasculature of skeletal muscle but the thrombosis appears to be partially reversible.

Full Text

Duke Authors

Cited Authors

  • Hartsock, LA; Seaber, AV; Urbaniak, JR

Published Date

  • 1989

Published In

Volume / Issue

  • 10 / 3

Start / End Page

  • 161 - 166

PubMed ID

  • 2796711

Pubmed Central ID

  • 2796711

International Standard Serial Number (ISSN)

  • 0738-1085

Digital Object Identifier (DOI)

  • 10.1002/micr.1920100303


  • eng

Conference Location

  • United States