Inhibition of epinephrine-induced vasospasm with adrenoreceptor blockade in the rat cremaster muscle.

Journal Article (Journal Article)

This study demonstrates that intravenous epinephrine causes arterial vasospasm, but not venous constriction, in the microcirculation of the rat cremaster muscle. This effect can be blocked by a smooth muscle relaxant such as papaverine or an alpha receptor antagonist such as phentolamine. Circulating vasospastic agents such as epinephrine are important determinants of microcirculatory blood flow, and inhibition by pharmacologic means may enhance blood flow and survival in microvascular surgery.

Full Text

Duke Authors

Cited Authors

  • Hartsock, LA; Seaber, AV; Urbaniak, JR

Published Date

  • 1991

Published In

Volume / Issue

  • 12 / 1

Start / End Page

  • 55 - 59

PubMed ID

  • 1990250

International Standard Serial Number (ISSN)

  • 0738-1085

Digital Object Identifier (DOI)

  • 10.1002/micr.1920120111


  • eng

Conference Location

  • United States