Inhibition of epinephrine-induced vasospasm with adrenoreceptor blockade in the rat cremaster muscle.
Journal Article (Journal Article)
This study demonstrates that intravenous epinephrine causes arterial vasospasm, but not venous constriction, in the microcirculation of the rat cremaster muscle. This effect can be blocked by a smooth muscle relaxant such as papaverine or an alpha receptor antagonist such as phentolamine. Circulating vasospastic agents such as epinephrine are important determinants of microcirculatory blood flow, and inhibition by pharmacologic means may enhance blood flow and survival in microvascular surgery.
Full Text
Duke Authors
Cited Authors
- Hartsock, LA; Seaber, AV; Urbaniak, JR
Published Date
- 1991
Published In
Volume / Issue
- 12 / 1
Start / End Page
- 55 - 59
PubMed ID
- 1990250
International Standard Serial Number (ISSN)
- 0738-1085
Digital Object Identifier (DOI)
- 10.1002/micr.1920120111
Language
- eng
Conference Location
- United States