Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion.

Journal Article

The gene most commonly altered in human glioblastomas is the epidermalgrowth factor receptor (EGFR). We profiled transcripts induced by mutantEGFR to better understand its role in tumor progression. The pattern found suggested enhanced tumor invasion. The highly induced genes included extracellular matrix components, metalloproteases, and a serine protease. We confirmed that mutant EGFR did make glioblastoma cells both more motile and invasive using in vitro assays. Furthermore, inhibitors of EGFR (OSI-774 and Tyrphostin AG1478) selectively down-regulated these molecular effectors in glioblastoma cells, eliminating enhanced invasion.

Full Text

Duke Authors

Cited Authors

  • Lal, A; Glazer, CA; Martinson, HM; Friedman, HS; Archer, GE; Sampson, JH; Riggins, GJ

Published Date

  • June 15, 2002

Published In

Volume / Issue

  • 62 / 12

Start / End Page

  • 3335 - 3339

PubMed ID

  • 12067969

International Standard Serial Number (ISSN)

  • 0008-5472

Language

  • eng

Conference Location

  • United States