Intrinsic optical changes in neuronal tissue. Basic mechanisms.


Journal Article (Review)

Associated with changes in the level of physiological activity in neuronal tissue are changes in the intrinsic optical properties of the tissue. As a consequence, it is possible to optically monitor neuronal activity without the use of dyes or other contrast-enhancing agents. Such optical techniques have been applied in the laboratory for more than 50 years. Recent developments in near-infrared spectroscopy and intraoperative optical imaging have suggested a number of clinically important applications of this technology. This article provides an overview of what is known about the physiological correlates and underlying mechanisms associated with activity-evoked optical changes in neuronal tissue.

Full Text

Cited Authors

  • Hochman, DW

Published Date

  • July 1997

Published In

Volume / Issue

  • 8 / 3

Start / End Page

  • 393 - 412

PubMed ID

  • 9188546

Pubmed Central ID

  • 9188546

Electronic International Standard Serial Number (EISSN)

  • 1558-1349

International Standard Serial Number (ISSN)

  • 1042-3680

Digital Object Identifier (DOI)

  • 10.1016/s1042-3680(18)30312-7


  • eng