The role of mechanical loading in the onset and progression of osteoarthritis.


Journal Article (Review)

Osteoarthritis is a progressive joint disease characterized by an imbalance of articular cartilage biosynthesis and degradation attributed to both inflammatory and biomechanical factors. Whereas moderate mechanical loading appears necessary for maintaining healthy cartilage, abnormal joint loading increases the risk of osteoarthritis. Obesity-induced osteoarthritis and the benefits of physical activity may be mediated by systemic levels of proinflammatory mediators as well as local biomechanical factors in the joint.

Full Text

Cited Authors

  • Griffin, TM; Guilak, F

Published Date

  • October 2005

Published In

Volume / Issue

  • 33 / 4

Start / End Page

  • 195 - 200

PubMed ID

  • 16239837

Pubmed Central ID

  • 16239837

Electronic International Standard Serial Number (EISSN)

  • 1538-3008

International Standard Serial Number (ISSN)

  • 0091-6331

Digital Object Identifier (DOI)

  • 10.1097/00003677-200510000-00008


  • eng