Skip to main content
Journal cover image

Total respiratory support from swine lungs in primate recipients.

Publication ,  Journal Article
Daggett, CW; Yeatman, M; Lodge, AJ; Chen, EP; Linn, SS; Gullotto, C; Frank, MM; Platt, JL; Davis, RD
Published in: J Thorac Cardiovasc Surg
January 1998

UNLABELLED: The use of nonhuman lung donors, such as swine, has the potential to provide an unlimited supply of organs. However, hyperacute rejection has prevented pulmonary xenotransplantation. OBJECTIVE: Our aim was to test the hypothesis that immunodepletion by pretransplantation swine lung perfusion will prevent hyperacute swine-to-primate pulmonary xenograft rejection and allow for a functional swine pulmonary xenograft. METHODS: Seven baboons underwent left pneumonectomy followed by orthotopic transplantation of the swine left lung. Four baboons received immunodepletion by perfusion with swine lungs before transplantation, and three received no treatment before transplantation. RESULTS: After transplantation, pulmonary xenografts from immunodepleted baboons had a low pulmonary vascular resistance and a high pulmonary blood flow compared with control animals, which had a high pulmonary vascular resistance and a low pulmonary blood flow. After 60 minutes of reperfusion, three of four immunodepleted animals also tolerated complete occlusion of the right pulmonary artery, with the baboon relying completely on the swine pulmonary xenograft for respiratory function for 11 hours. Pathologic analysis of peripheral lung biopsy specimens taken from control lungs displayed alveolar disruption and hemorrhage within small vessels, whereas swine lungs transplanted into immunodepleted baboons displayed little histologic evidence of injury. Furthermore, pulmonary xenografts transplanted into immunodepleted baboons demonstrated excellent respiratory function and adequate hemodynamics during occlusion of the right pulmonary artery. CONCLUSION: Hyperacute pulmonary xenograft rejection can be prevented by pretransplantation swine lung perfusion. Swine pulmonary xenografts can provide complete respiratory support in primates when rejection is prevented.

Duke Scholars

Published In

J Thorac Cardiovasc Surg

DOI

ISSN

0022-5223

Publication Date

January 1998

Volume

115

Issue

1

Start / End Page

19 / 27

Location

United States

Related Subject Headings

  • Transplantation, Heterologous
  • Swine
  • Respiratory System
  • Pulmonary Circulation
  • Premedication
  • Perfusion
  • Papio
  • Lung Transplantation
  • Lung
  • Immunosuppressive Agents
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Daggett, C. W., Yeatman, M., Lodge, A. J., Chen, E. P., Linn, S. S., Gullotto, C., … Davis, R. D. (1998). Total respiratory support from swine lungs in primate recipients. J Thorac Cardiovasc Surg, 115(1), 19–27. https://doi.org/10.1016/s0022-5223(98)70438-6
Daggett, C. W., M. Yeatman, A. J. Lodge, E. P. Chen, S. S. Linn, C. Gullotto, M. M. Frank, J. L. Platt, and R. D. Davis. “Total respiratory support from swine lungs in primate recipients.J Thorac Cardiovasc Surg 115, no. 1 (January 1998): 19–27. https://doi.org/10.1016/s0022-5223(98)70438-6.
Daggett CW, Yeatman M, Lodge AJ, Chen EP, Linn SS, Gullotto C, et al. Total respiratory support from swine lungs in primate recipients. J Thorac Cardiovasc Surg. 1998 Jan;115(1):19–27.
Daggett, C. W., et al. “Total respiratory support from swine lungs in primate recipients.J Thorac Cardiovasc Surg, vol. 115, no. 1, Jan. 1998, pp. 19–27. Pubmed, doi:10.1016/s0022-5223(98)70438-6.
Daggett CW, Yeatman M, Lodge AJ, Chen EP, Linn SS, Gullotto C, Frank MM, Platt JL, Davis RD. Total respiratory support from swine lungs in primate recipients. J Thorac Cardiovasc Surg. 1998 Jan;115(1):19–27.
Journal cover image

Published In

J Thorac Cardiovasc Surg

DOI

ISSN

0022-5223

Publication Date

January 1998

Volume

115

Issue

1

Start / End Page

19 / 27

Location

United States

Related Subject Headings

  • Transplantation, Heterologous
  • Swine
  • Respiratory System
  • Pulmonary Circulation
  • Premedication
  • Perfusion
  • Papio
  • Lung Transplantation
  • Lung
  • Immunosuppressive Agents