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Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice.

Publication ,  Journal Article
Rockman, HA; Koch, WJ; Milano, CA; Lefkowitz, RJ
Published in: J Mol Med (Berl)
September 1996

Heart failure is a problem of increasing importance in cardiovascular medicine. An important characteristic of heart failure is reduced agonist-stimulated adenylyl cyclase activity (receptor desensitization) due to both diminished receptor number (receptor downregulation) and impaired receptor function (receptor uncoupling). These changes in the section-adrenergic receptor (section-AR) system may in part account for some of the abnormalities of contractile function in this disease. Myocardial contraction is closely regulated by G protein coupled beta-adrenergic receptors through the action of the second messenger cAMP. The beta-adrenergic receptors themselves are regulated by a set of specific kinases, termed the G-protein-coupled receptor kinases. The study of this complex system in vivo has recently been advanced by the development of transgenic and gene targeted ("knockout") mouse models. Combining transgenic technology with sophisticated physiological measurements of cardiac hemodynamics is an extremely powerful strategy to study the regulation of myocardial contractility in the normal and failing heart.

Duke Scholars

Published In

J Mol Med (Berl)

DOI

ISSN

0946-2716

Publication Date

September 1996

Volume

74

Issue

9

Start / End Page

489 / 495

Location

Germany

Related Subject Headings

  • beta-Adrenergic Receptor Kinases
  • Signal Transduction
  • Receptors, Adrenergic, beta
  • Myocardium
  • Mice, Transgenic
  • Mice
  • Isoproterenol
  • Immunology
  • Immunohistochemistry
  • Hemodynamics
 

Citation

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Rockman, H. A., Koch, W. J., Milano, C. A., & Lefkowitz, R. J. (1996). Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice. J Mol Med (Berl), 74(9), 489–495. https://doi.org/10.1007/BF00204974
Rockman, H. A., W. J. Koch, C. A. Milano, and R. J. Lefkowitz. “Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice.J Mol Med (Berl) 74, no. 9 (September 1996): 489–95. https://doi.org/10.1007/BF00204974.
Rockman HA, Koch WJ, Milano CA, Lefkowitz RJ. Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice. J Mol Med (Berl). 1996 Sep;74(9):489–95.
Rockman, H. A., et al. “Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice.J Mol Med (Berl), vol. 74, no. 9, Sept. 1996, pp. 489–95. Pubmed, doi:10.1007/BF00204974.
Rockman HA, Koch WJ, Milano CA, Lefkowitz RJ. Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice. J Mol Med (Berl). 1996 Sep;74(9):489–495.
Journal cover image

Published In

J Mol Med (Berl)

DOI

ISSN

0946-2716

Publication Date

September 1996

Volume

74

Issue

9

Start / End Page

489 / 495

Location

Germany

Related Subject Headings

  • beta-Adrenergic Receptor Kinases
  • Signal Transduction
  • Receptors, Adrenergic, beta
  • Myocardium
  • Mice, Transgenic
  • Mice
  • Isoproterenol
  • Immunology
  • Immunohistochemistry
  • Hemodynamics