Risk of anaphylaxis from aprotinin re-exposure during LVAD removal and heart transplantation.
Journal Article
Aprotinin has been shown to reduce transfusion requirements in re-operative cardiac surgery and in implantation of long-term left ventricular assist devices (LVAD). However, it is an antigenic polypeptide and re-exposure is associated with a small incidence of anaphylaxis. This report describes 2 cases of anaphylactic response to aprotinin when the agent was employed for both the LVAD implant and for the subsequent explant and cardiac transplant. Early re-exposure to just the test dose was associated with a significant incidence of anaphylaxis.
Full Text
Duke Authors
Cited Authors
- Milano, CA; Patel, VS; Smith, PK; Smith, MS
Published Date
- October 2002
Published In
Volume / Issue
- 21 / 10
Start / End Page
- 1127 - 1130
PubMed ID
- 12398879
Pubmed Central ID
- 12398879
International Standard Serial Number (ISSN)
- 1053-2498
Digital Object Identifier (DOI)
- 10.1016/s1053-2498(02)00395-9
Language
- eng
Conference Location
- United States