Gene delivery systems in surgery.

Journal Article (Journal Article;Review)

Increased understanding of the genetic basis of human disease has led to a number of potential gene-based therapies for various medical and surgical disorders. The development of efficient methods for delivering genes to mammalian cells in vitro has increased the potential clinical utility of gene-based therapies; however, a major focus of research has been more efficient delivery to appropriate target cells, in vivo as well as in vitro, to establish gene therapy as an effective clinical modality for common disorders. Despite substantial progress, a number of critical technical issues to enhance and optimize not only gene transfer but also gene expression must be resolved. These future technological developments will be essential for the widespread clinical implementation of gene-based therapy.

Full Text

Duke Authors

Cited Authors

  • Lyerly, HK; DiMaio, JM

Published Date

  • November 1993

Published In

Volume / Issue

  • 128 / 11

Start / End Page

  • 1197 - 1206

PubMed ID

  • 8239982

International Standard Serial Number (ISSN)

  • 0004-0010

Digital Object Identifier (DOI)

  • 10.1001/archsurg.1993.01420230025004


  • eng

Conference Location

  • United States