Immunotherapy of cancer using dendritic cells.

Journal Article (Journal Article;Review)

While the promise of harnessing the immune system for a therapeutic effect has remained largely unfulfilled for many years, the discovery of the central role of dendritic cells in stimulating antigen-specific immune responses has prompted new enthusiasm for immunotherapy of malignancies. Elucidation of the pathways of dendritic cell development and trafficking, acquisition and processing of antigen, and stimulation of T cells has suggested methods for generating and antigen-loading dendritic cells for use in immunotherapy protocols. Animal models have demonstrated that dendritic cells can stimulate protective antitumor responses in vivo. Phase I clinical trials have been initiated to address the safety and feasibility of immunizations with dendritic cells in humans with various malignancies.

Full Text

Duke Authors

Cited Authors

  • Morse, MA; Lyerly, HK

Published Date

  • March 1, 1998

Published In

Volume / Issue

  • 4 / 1

Start / End Page

  • 35 - 44

PubMed ID

  • 9557215

International Standard Serial Number (ISSN)

  • 1368-4736


  • eng

Conference Location

  • England