Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1.
Journal Article (Journal Article)
Cells of the monocyte-macrophage lineage are targets for human immunodeficiency virus-1 (HIV-1) infection in vivo. However, many laboratory strains of HIV-1 that efficiently infect transformed T cell lines replicate poorly in macrophages. A 20-amino acid sequence from the macrophage-tropic BaL isolate of HIV-1 was sufficient to confer macrophage tropism on HTLV-IIIB, a T cell line--tropic isolate. This small sequence element is in the V3 loop, the envelope domain that is the principal neutralizing determinant of HIV-1. Thus, the V3 loop not only serves as a target of the host immune response but is also pivotal in determining HIV-1 tissue tropism.
- Hwang, SS; Boyle, TJ; Lyerly, HK; Cullen, BR
- July 5, 1991
Volume / Issue
- 253 / 5015
Start / End Page
- 71 - 74
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)
- United States