Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1.

Published

Journal Article

Cells of the monocyte-macrophage lineage are targets for human immunodeficiency virus-1 (HIV-1) infection in vivo. However, many laboratory strains of HIV-1 that efficiently infect transformed T cell lines replicate poorly in macrophages. A 20-amino acid sequence from the macrophage-tropic BaL isolate of HIV-1 was sufficient to confer macrophage tropism on HTLV-IIIB, a T cell line--tropic isolate. This small sequence element is in the V3 loop, the envelope domain that is the principal neutralizing determinant of HIV-1. Thus, the V3 loop not only serves as a target of the host immune response but is also pivotal in determining HIV-1 tissue tropism.

Full Text

Duke Authors

Cited Authors

  • Hwang, SS; Boyle, TJ; Lyerly, HK; Cullen, BR

Published Date

  • July 1991

Published In

Volume / Issue

  • 253 / 5015

Start / End Page

  • 71 - 74

PubMed ID

  • 1905842

Pubmed Central ID

  • 1905842

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1905842

Language

  • eng