HER2/neu-derived peptides are shared antigens among human non-small cell lung cancer and ovarian cancer.

Journal Article (Journal Article)

Previously, we have reported a correlation between the expression of HER2/neu and sensitivity to HLA-A2-restricted cytotoxic T-cells (CTL) in ovarian cancer. To investigate the role of HER2/neu in human non-small cell lung cancer (NSCLC), we established autologous tumor-specific CTL from tumor-infiltrating lymphocytes of HLA-A2+ HER2/neu+ NSCLC patients. These CTL lines specifically recognized HLA-A2+ HER2/neu+ autologous and allogeneic NSCLC cell lines as well as HLA-A2+ HER2/neu+ heterologous ovarian cancer cell lines. Furthermore, these CTL recognized an overexpressed, HER2/neu-derived peptide. From these results, we conclude that HLA-A2 serves as a restriction element in NSCLC. More importantly, at least one HER2/neu-derived peptide is a tumor-associated antigen in NSCLC and ovarian cancer.

Full Text

Duke Authors

Cited Authors

  • Yoshino, I; Goedegebuure, PS; Peoples, GE; Parikh, AS; DiMaio, JM; Lyerly, HK; Gazdar, AF; Eberlein, TJ

Published Date

  • July 1, 1994

Published In

Volume / Issue

  • 54 / 13

Start / End Page

  • 3387 - 3390

PubMed ID

  • 7912166

International Standard Serial Number (ISSN)

  • 0008-5472


  • eng

Conference Location

  • United States