Skip to main content

HER2/neu-derived peptides are shared antigens among human non-small cell lung cancer and ovarian cancer.

Publication ,  Journal Article
Yoshino, I; Goedegebuure, PS; Peoples, GE; Parikh, AS; DiMaio, JM; Lyerly, HK; Gazdar, AF; Eberlein, TJ
Published in: Cancer Res
July 1, 1994

Previously, we have reported a correlation between the expression of HER2/neu and sensitivity to HLA-A2-restricted cytotoxic T-cells (CTL) in ovarian cancer. To investigate the role of HER2/neu in human non-small cell lung cancer (NSCLC), we established autologous tumor-specific CTL from tumor-infiltrating lymphocytes of HLA-A2+ HER2/neu+ NSCLC patients. These CTL lines specifically recognized HLA-A2+ HER2/neu+ autologous and allogeneic NSCLC cell lines as well as HLA-A2+ HER2/neu+ heterologous ovarian cancer cell lines. Furthermore, these CTL recognized an overexpressed, HER2/neu-derived peptide. From these results, we conclude that HLA-A2 serves as a restriction element in NSCLC. More importantly, at least one HER2/neu-derived peptide is a tumor-associated antigen in NSCLC and ovarian cancer.

Duke Scholars

Published In

Cancer Res

ISSN

0008-5472

Publication Date

July 1, 1994

Volume

54

Issue

13

Start / End Page

3387 / 3390

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • T-Lymphocytes, Cytotoxic
  • Receptor, erbB-2
  • Receptor, ErbB-2
  • Proto-Oncogene Proteins
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Lung Neoplasms
  • Humans
  • HLA-A2 Antigen
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yoshino, I., Goedegebuure, P. S., Peoples, G. E., Parikh, A. S., DiMaio, J. M., Lyerly, H. K., … Eberlein, T. J. (1994). HER2/neu-derived peptides are shared antigens among human non-small cell lung cancer and ovarian cancer. Cancer Res, 54(13), 3387–3390.
Yoshino, I., P. S. Goedegebuure, G. E. Peoples, A. S. Parikh, J. M. DiMaio, H. K. Lyerly, A. F. Gazdar, and T. J. Eberlein. “HER2/neu-derived peptides are shared antigens among human non-small cell lung cancer and ovarian cancer.Cancer Res 54, no. 13 (July 1, 1994): 3387–90.
Yoshino I, Goedegebuure PS, Peoples GE, Parikh AS, DiMaio JM, Lyerly HK, et al. HER2/neu-derived peptides are shared antigens among human non-small cell lung cancer and ovarian cancer. Cancer Res. 1994 Jul 1;54(13):3387–90.
Yoshino, I., et al. “HER2/neu-derived peptides are shared antigens among human non-small cell lung cancer and ovarian cancer.Cancer Res, vol. 54, no. 13, July 1994, pp. 3387–90.
Yoshino I, Goedegebuure PS, Peoples GE, Parikh AS, DiMaio JM, Lyerly HK, Gazdar AF, Eberlein TJ. HER2/neu-derived peptides are shared antigens among human non-small cell lung cancer and ovarian cancer. Cancer Res. 1994 Jul 1;54(13):3387–3390.

Published In

Cancer Res

ISSN

0008-5472

Publication Date

July 1, 1994

Volume

54

Issue

13

Start / End Page

3387 / 3390

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • T-Lymphocytes, Cytotoxic
  • Receptor, erbB-2
  • Receptor, ErbB-2
  • Proto-Oncogene Proteins
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Lung Neoplasms
  • Humans
  • HLA-A2 Antigen