Migration of human dendritic cells after injection in patients with metastatic malignancies.

Published

Journal Article

Present clinical studies of active immunotherapy for malignancies using dendritic cells (DCs) require elucidation of the sites where DCs localize after injection. We evaluated the pattern of distribution of in vitro-generated, antigen-loaded, human DCs labeled with indium-111 oxyquinoline after i.v., s.c., and intradermal injection. Whereas the DCs injected i.v. localized in the lungs and then redistributed to the liver, spleen, and bone marrow, they were not detected in lymph nodes or tumors. A small percentage of DCs injected intradermally migrated rapidly to the regional lymphatics in some individuals. No lymph node activity was detected after s.c. injection. Our results demonstrate that DC distribution to sites of lymphoid tissue is dramatically affected by the mode of administration.

Full Text

Duke Authors

Cited Authors

  • Morse, MA; Coleman, RE; Akabani, G; Niehaus, N; Coleman, D; Lyerly, HK

Published Date

  • January 1999

Published In

Volume / Issue

  • 59 / 1

Start / End Page

  • 56 - 58

PubMed ID

  • 9892184

Pubmed Central ID

  • 9892184

Electronic International Standard Serial Number (EISSN)

  • 1538-7445

International Standard Serial Number (ISSN)

  • 0008-5472

Language

  • eng