Isolation of a nuclease-resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodies.
Journal Article (Journal Article)
The muscular weakness and fatigability associated with myasthenia gravis are engendered by autoantibodies directed against acetylcholine receptors on muscle cells at neuromuscular junctions. The pathogenic consequences of this immune response can potentially be modulated by molecules that bind such autoantibodies and block their interaction with these receptors. We report the isolation of a small nuclease-resistant RNA molecule that binds both a rat monoclonal antibody that recognizes the main immunogenic region on the acetylcholine receptor, and autoantibodies from patients with myasthenia gravis. Moreover, this RNA can act as a decoy and protect acetylcholine receptors on human cells from the effects of these antibodies.
Full Text
Duke Authors
Cited Authors
- Lee, SW; Sullenger, BA
Published Date
- January 1997
Published In
Volume / Issue
- 15 / 1
Start / End Page
- 41 - 45
PubMed ID
- 9035104
International Standard Serial Number (ISSN)
- 1087-0156
Digital Object Identifier (DOI)
- 10.1038/nbt0197-41
Language
- eng
Conference Location
- United States