Ribozyme-mediated repair of RNAs encoding mutant tumor suppressors.

Journal Article (Journal Article;Review)

The observation that a number of genetic mutations can result in neoplastic transformation has led many investigators to speculate that gene therapy may represent a useful approach to treat cancer. Conceptually, this application of gene therapy seems quite simple: to treat cancer, restore the correctly regulated expression of the needed tumor suppressor genes inside tumor cells and revert the transformed phenotype of such cells. However, such regulated expression has been difficult to achieve in practice. Here we describe recent efforts at such restoration via a novel approach to gene therapy that involves ribozyme-mediated repair of mutant RNA transcripts.

Full Text

Duke Authors

Cited Authors

  • Sullenger, BA

Published Date

  • September 1996

Published In

Volume / Issue

  • 2 / 3

Start / End Page

  • 201 - 205

PubMed ID

  • 9384705

International Standard Serial Number (ISSN)

  • 1355-6568


  • eng

Conference Location

  • England