The effect of quinidine, propranolol and their combination on experimental atrial and ventricular arrhythmias.

Journal Article (Journal Article)

The comparative antiarrhythmic activity of quinidine, propranolol and the combination of these two drugs was studied in experimental atrial and ventricular arrhythmias in the dog. Quinidine, but not propranolol, suppressed atrial arrhythmias produced by topical application of aconitine to the atrium, as well as the ventricular arrhythmias that developed approximately 20 hr following coronary artery ligation. When the two drugs were coadministered, synergism occurred in the atrial arrhthmias but not in the ventricular arrhythmias. Some possible mechanisms of action of these drugs are discussed. The change in response to quinidine by coadministration with propranolol may have resulted in part from suppression of atrial automaticity in the aconitine experiments and from further slowing of ventricular conduction in the coronary artery ligation experiments. Both effects might have occurred as a result of myocardial beta adrenergic receptor blockade.

Full Text

Duke Authors

Cited Authors

  • Lawson, JH; Wojciechowski, NJ

Published Date

  • October 1, 1977

Published In

Volume / Issue

  • 229 / 2

Start / End Page

  • 235 - 243

PubMed ID

  • 596978

International Standard Serial Number (ISSN)

  • 0003-9780


  • eng

Conference Location

  • Belgium