A seven-month survival of a calf with an artificial heart designed for human use.

Journal Article (Journal Article)

A Jarvik-7 type of pneumatic artificial heart, which was specifically designed to fit the anatomy and hemodynamic requirements of human patients, was implanted in a calf in an experiment to test the hemodynamic performance of the artificial heart. The experiment lasted for 221 days, longer than any animal had ever lived without its natural heart, despite the fact that the calf increased its body weight to 171 kg. The calf showed typical signs of low cardiac output before its death, but the direct cause of death was intestinal bleeding. At autopsy, it was discovered that the low cardiac output was due to severe pannus around the left inflow valve, as diagnosed earlier by changes in the pneumatic pressure wave form.

Full Text

Duke Authors

Cited Authors

  • Mochizuki, T; Lawson, JH; Olsen, DB; Fukumasu, H; Daitoh, N; Jarvik, R; Kessler, TR; Pons, AB; Hastings, L; Razzeca, KJ; Nielsen, SD; Kolff, WJ

Published Date

  • May 1, 1981

Published In

Volume / Issue

  • 5 / 2

Start / End Page

  • 125 - 131

PubMed ID

  • 7271525

International Standard Serial Number (ISSN)

  • 0160-564X

Digital Object Identifier (DOI)

  • 10.1111/j.1525-1594.1981.tb03974.x


  • eng

Conference Location

  • United States