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Humoral responses to pig-to-baboon cardiac transplantation: implications for the pathogenesis and treatment of acute vascular rejection and for accommodation.

Publication ,  Journal Article
McCurry, KR; Parker, W; Cotterell, AH; Weidner, BC; Lin, SS; Daniels, LJ; Holzknecht, ZE; Byrne, GW; Diamond, LE; Logan, JS; Platt, JL
Published in: Hum Immunol
December 1997

Organs transplanted between phylogenetically-disparate species, such as from the pig into the primate, are subject to hyperacute and acute vascular rejection. Hyperacute rejection of a porcine organ by a primate is thought to be initiated by the binding of xenoreactive natural antibodies to Galalpha1-3Gal expressed on the endothelial lining of blood vessels in the xenograft. The factor(s) which initiates acute vascular rejection is uncertain; however, there is some evidence implicating xenoreactive antibodies. The nature of the humoral response which might contribute to acute vascular rejection of a porcine organ was investigated in baboons which received a porcine cardiac xenograft plus immunosuppression with methylprednisolone, azathioprine, and cyclosporine. Following rejection and surgical removal of the xenografts, the serum concentration of xenoreactive antibodies increased in untreated animals but in immunosuppressed animals was similar to the concentration in preimmune serum. The antibodies in the sensitized recipients were specific for Galalpha1-3Gal (70-95%) and other determinants (5-30%). However, cross-blocking studies showed that, following xenotransplantation, the immunosuppressed baboons had no detectable IgM or IgG directed against "new" endothelial antigens. These results indicate that antibodies made by immunosuppressed individuals in response to xenotransplantation are much like xenoreactive natural antibodies and suggest that acute vascular rejection might in some cases be addressed by therapeutic strategies aimed at those antibodies.

Duke Scholars

Published In

Hum Immunol

DOI

ISSN

0198-8859

Publication Date

December 1997

Volume

58

Issue

2

Start / End Page

91 / 105

Location

United States

Related Subject Headings

  • Transplantation, Heterologous
  • Swine
  • Papio
  • Microscopy, Fluorescence
  • Integrins
  • Immunosuppression Therapy
  • Immunology
  • Immunohistochemistry
  • Humans
  • Heart Transplantation
 

Citation

APA
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ICMJE
MLA
NLM
McCurry, K. R., Parker, W., Cotterell, A. H., Weidner, B. C., Lin, S. S., Daniels, L. J., … Platt, J. L. (1997). Humoral responses to pig-to-baboon cardiac transplantation: implications for the pathogenesis and treatment of acute vascular rejection and for accommodation. Hum Immunol, 58(2), 91–105. https://doi.org/10.1016/s0198-8859(97)00229-2
McCurry, K. R., W. Parker, A. H. Cotterell, B. C. Weidner, S. S. Lin, L. J. Daniels, Z. E. Holzknecht, et al. “Humoral responses to pig-to-baboon cardiac transplantation: implications for the pathogenesis and treatment of acute vascular rejection and for accommodation.Hum Immunol 58, no. 2 (December 1997): 91–105. https://doi.org/10.1016/s0198-8859(97)00229-2.
McCurry KR, Parker W, Cotterell AH, Weidner BC, Lin SS, Daniels LJ, et al. Humoral responses to pig-to-baboon cardiac transplantation: implications for the pathogenesis and treatment of acute vascular rejection and for accommodation. Hum Immunol. 1997 Dec;58(2):91–105.
McCurry, K. R., et al. “Humoral responses to pig-to-baboon cardiac transplantation: implications for the pathogenesis and treatment of acute vascular rejection and for accommodation.Hum Immunol, vol. 58, no. 2, Dec. 1997, pp. 91–105. Pubmed, doi:10.1016/s0198-8859(97)00229-2.
McCurry KR, Parker W, Cotterell AH, Weidner BC, Lin SS, Daniels LJ, Holzknecht ZE, Byrne GW, Diamond LE, Logan JS, Platt JL. Humoral responses to pig-to-baboon cardiac transplantation: implications for the pathogenesis and treatment of acute vascular rejection and for accommodation. Hum Immunol. 1997 Dec;58(2):91–105.
Journal cover image

Published In

Hum Immunol

DOI

ISSN

0198-8859

Publication Date

December 1997

Volume

58

Issue

2

Start / End Page

91 / 105

Location

United States

Related Subject Headings

  • Transplantation, Heterologous
  • Swine
  • Papio
  • Microscopy, Fluorescence
  • Integrins
  • Immunosuppression Therapy
  • Immunology
  • Immunohistochemistry
  • Humans
  • Heart Transplantation