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Disseminated intravascular coagulation in association with pig-to-primate pulmonary xenotransplantation.

Publication ,  Journal Article
Gaca, JG; Lesher, A; Aksoy, O; Gonzalez-Stawinski, GV; Platt, JL; Lawson, JH; Parker, W; Davis, RD
Published in: Transplantation
June 15, 2002

BACKGROUND: Profound coagulopathy has been proposed as a barrier to xenotransplantation. Disseminated intravascular coagulation (DIC) has been observed with the rejection of renal and bone marrow xenografts but has not yet been described in pulmonary xenografts. METHODS: This study examined the coagulation parameters in five baboons that received pulmonary xenografts and one baboon that was exposed to porcine lung during an extracorporeal perfusion. Platelet counts, prothrombin times (PT), and levels of fibrinogen, D-dimers, and thrombin-antithrombin III complex (TAT) were analyzed. In addition, serum levels of plasminogen activator inhibitor-1 (PAI-1), thrombomodulin (TM), tissue plasminogen activator (tPA), and tissue factor (TF) were determined. RESULTS: Hyperacute pulmonary xenograft dysfunction, which occurred within 0-9 hr of graft reperfusion, was associated with clinically evident DIC. This coagulopathy was characterized by thrombocytopenia, decreased fibrinogen levels, elevations in PT, and increases in D-dimers and TAT. Furthermore, transient increases in PAI-1, increases in TM, and increases in tPA were observed in the serum of some but not all recipients. None of the baboons demonstrated measurable increases in soluble TF. CONCLUSIONS: Although DIC in renal or bone marrow xenotransplantation develops over a period of days, DIC associated with hyperacute pulmonary xenograft dysfunction develops within hours of graft reperfusion. Thus, the DIC in pulmonary xenotransplantation may represent a unique and/or accelerated version of the coagulopathy observed with renal and bone marrow xenotransplantation.

Duke Scholars

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

June 15, 2002

Volume

73

Issue

11

Start / End Page

1717 / 1723

Location

United States

Related Subject Headings

  • Transplantation, Heterologous
  • Swine
  • Surgery
  • Prothrombin Time
  • Platelet Count
  • Peptide Hydrolases
  • Papio
  • Lung Transplantation
  • Fibrinogen
  • Fibrin Fibrinogen Degradation Products
 

Citation

APA
Chicago
ICMJE
MLA
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Gaca, J. G., Lesher, A., Aksoy, O., Gonzalez-Stawinski, G. V., Platt, J. L., Lawson, J. H., … Davis, R. D. (2002). Disseminated intravascular coagulation in association with pig-to-primate pulmonary xenotransplantation. Transplantation, 73(11), 1717–1723. https://doi.org/10.1097/00007890-200206150-00005
Gaca, Jeffrey G., Aaron Lesher, Olcay Aksoy, Gonzalo V. Gonzalez-Stawinski, Jeffrey L. Platt, Jeffrey H. Lawson, William Parker, and R Duane Davis. “Disseminated intravascular coagulation in association with pig-to-primate pulmonary xenotransplantation.Transplantation 73, no. 11 (June 15, 2002): 1717–23. https://doi.org/10.1097/00007890-200206150-00005.
Gaca JG, Lesher A, Aksoy O, Gonzalez-Stawinski GV, Platt JL, Lawson JH, et al. Disseminated intravascular coagulation in association with pig-to-primate pulmonary xenotransplantation. Transplantation. 2002 Jun 15;73(11):1717–23.
Gaca, Jeffrey G., et al. “Disseminated intravascular coagulation in association with pig-to-primate pulmonary xenotransplantation.Transplantation, vol. 73, no. 11, June 2002, pp. 1717–23. Pubmed, doi:10.1097/00007890-200206150-00005.
Gaca JG, Lesher A, Aksoy O, Gonzalez-Stawinski GV, Platt JL, Lawson JH, Parker W, Davis RD. Disseminated intravascular coagulation in association with pig-to-primate pulmonary xenotransplantation. Transplantation. 2002 Jun 15;73(11):1717–1723.

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

June 15, 2002

Volume

73

Issue

11

Start / End Page

1717 / 1723

Location

United States

Related Subject Headings

  • Transplantation, Heterologous
  • Swine
  • Surgery
  • Prothrombin Time
  • Platelet Count
  • Peptide Hydrolases
  • Papio
  • Lung Transplantation
  • Fibrinogen
  • Fibrin Fibrinogen Degradation Products