Isohemagglutinins and xenoreactive antibodies: members of a distinct family of natural antibodies.


Journal Article

Just as anti-blood group A and anti-blood group B antibodies pose a strong humoral barrier to the transplantation of allogeneic organs or blood, xenoreactive natural antibodies directed against Gal alpha 1-3Gal pose a barrier to the transplantation of xenogeneic organs or blood. We tested the idea that, although "natural" iso-hemagglutinins and xenoreactive natural antibodies recognize distinct structures, they have a similar origin and function. Anti-A antibodies, anti-B antibodies, and xenoreactive natural antibodies were present in serum at similar concentrations and varied with age, gender, and the concentration of total IgM in serum in a similar manner. Anti-A antibodies, anti-B antibodies, and xenoreactive natural antibodies, unlike some elicited antibodies, had a high degree of thermal lability and bound more avidly at lower temperatures. The natural antibodies manifest remarkable homogeneity and high functional avidity for determinants on a cell surface but only a weak affinity for monovalent ligands. These findings suggest that anti-A antibodies, anti-B antibodies, and xenoreactive natural antibodies specific for Gal alpha 1-3Gal have a common origin and function and, given similar antigen density on target cells, provide similar humoral barriers to transplantation or transfusion and that these antibodies may be members of a common "family" of antibodies.

Full Text

Duke Authors

Cited Authors

  • Parker, W; Lundberg-Swanson, K; Holzknecht, ZE; Lateef, J; Washburn, SA; Braedehoeft, SJ; Platt, JL

Published Date

  • February 1996

Published In

Volume / Issue

  • 45 / 2

Start / End Page

  • 94 - 104

PubMed ID

  • 8882406

Pubmed Central ID

  • 8882406

International Standard Serial Number (ISSN)

  • 0198-8859

Digital Object Identifier (DOI)

  • 10.1016/0198-8859(95)00216-2


  • eng

Conference Location

  • United States