Antihuman factor V antibodies after use of relatively pure bovine thrombin.

Journal Article

Although bovine thrombin is commonly used in the operating room, there is evidence that exposure to bovine thrombin can result in the development of autoimmune antibodies, usually against factor V, which can lead to a profound coagulopathy. It is thought that impurities in bovine thrombin preparations are responsible for the adverse reactions in patients. Here we describe a case in which exposure to a relatively pure bovine thrombin preparation resulted in the development of an antihuman factor V antibody-associated coagulopathy. This report calls into question the safety of even relatively pure bovine thrombin.

Full Text

Duke Authors

Cited Authors

  • Lawson, JH; Lynn, KA; Vanmatre, RM; Domzalski, T; Klemp, KF; Ortel, TL; Niklason, LE; Parker, W

Published Date

  • March 2005

Published In

Volume / Issue

  • 79 / 3

Start / End Page

  • 1037 - 1038

PubMed ID

  • 15734434

Pubmed Central ID

  • 15734434

Electronic International Standard Serial Number (EISSN)

  • 1552-6259

Digital Object Identifier (DOI)

  • 10.1016/j.athoracsur.2003.09.110


  • eng

Conference Location

  • Netherlands